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Metal-ligand cooperation in the catalytic dehydrogenative coupling (DHC) of polyalcohols to carboxylic acid derivatives.

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Publication date 2011
Author Trincado Mónica, Kühlein Klaus, Grützmacher Hansjörg,
Project Unconventional Approaches to the Activation of Dihydrogen (FOR 1175) (D-A-CH/LAE)
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Original article (peer-reviewed)

Journal Chemistry (Weinheim an der Bergstrasse, Germany)
Volume (Issue) 17(42)
Page(s) 11905 - 13
Title of proceedings Chemistry (Weinheim an der Bergstrasse, Germany)
DOI 10.1002/chem.201101084


Several polyols, which are easily available from sugars through biochemical conversion or hydrogenolytic cleavage, are directly converted into carboxylic acids and amides. This efficient dehydrogenative coupling process, catalyzed by a rhodium(I) diolefin amido complex, is an attractive approach for the production of organic fine chemicals from renewable resources. This method tolerates the presence of several hydroxy groups and can be extended to the direct synthesis of lactams from the corresponding amino alcohols under mild conditions.