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Synthesis of different glutathione–sulfur mustard adducts of verified and potential biomarkers

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Bielmann Andreas, Sambiagio Nicolas, Wehr Nathalie, Gerber-Lemaire Sandrine, Bochet Christian G., Curty Christophe,
Project Photons in organic synthesis
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Original article (peer-reviewed)

Journal RSC Advances
Volume (Issue) 8(42)
Page(s) 23881 - 23890
Title of proceedings RSC Advances
DOI 10.1039/c8ra03360a

Open Access

URL http://doi.org/10.1039/C8RA03360A
Type of Open Access Publisher (Gold Open Access)

Abstract

Sulfur Mustard (SM) is a blistering agent used as a chem. weapon.  Glutathione (GSH) is involved in the β-lyase degrdn. pathway of SM and recently, bioadducts between SM and GSH were obsd. in vitro.  While these bioadducts have never been isolated from in vivo tests or real poisoning with SM, they could be of interest as potential future biomarkers for the retrospective validation of exposure.  We herein report the synthesis of different obsd. and new potential GSH-SM bioadducts as ref. materials for anal. investigation.  Two distinct approaches were investigated: a building-block pathway and the direct reaction with GSH.  The availability of these refs. will aid future studies and may lead to the discovery of new GSH-SM biomarkers.
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