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Broadly neutralizing antibodies: What is needed to move from a rare event in HIV-1 infection to vaccine efficacy?

Type of publication Peer-reviewed
Publikationsform Review article (peer-reviewed)
Author Subbaraman Harini, Schanz Merle, Trkola Alexandra,
Project Understanding HIV-1 broadly neutralizing antibody evolution - The Swiss 4.5K Screen
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Review article (peer-reviewed)

Journal Retrovirology
Volume (Issue) 15(1)
Page(s) 52 - 52
Title of proceedings Retrovirology
DOI 10.1186/s12977-018-0433-2

Open Access

URL http://doi.org/10.1186/s12977-018-0433-2
Type of Open Access Publisher (Gold Open Access)

Abstract

The elicitation of broadly neutralizing antibodies (bnAbs) is considered crucial for an effective, preventive HIV-1 vaccine. Led by the discovery of a new generation of potent bnAbs, the field has significantly advanced over the past decade. There is a wealth of knowledge about the development of bnAbs in natural infection, their specificity, potency, breadth and function. Yet, devising immunogens and vaccination regimens that evoke bnAb responses has not been successful. Where are the roadblocks in their development? What can we learn from natural infection, where bnAb induction is possible but rare? Herein, we will reflect on key discoveries and discuss open questions that may bear crucial insights needed to move towards creating effective bnAb vaccines.
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