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Antimicrobial silver-filled silica nanorattles with low immunotoxicity in dendritic cells

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Priebe Magdalena, Widmer Jérôme, Suhartha Löwa Nina, Abram Sarah-Luise, Mottas Inès, Woischnig Anne-Kathrin, Brunetto Priscilla S., Khanna Nina, Bourquin Carole, Fromm Katharina M.,
Project RLR/TLR combination therapy: Mechanisms of T-cell recruitment into gastric tumors
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Original article (peer-reviewed)

Journal Nanomedicine: Nanotechnology, Biology and Medicine
Volume (Issue) 13(1)
Page(s) 11 - 22
Title of proceedings Nanomedicine: Nanotechnology, Biology and Medicine
DOI 10.1016/j.nano.2016.08.002


The progression in the use of orthopedic implants has led to an increase in the absolute number of implant infections, triggering a search for more effective antibacterial coatings. Nanorattles have recently gained interest in biomedical applications such as drug delivery, as encapsulation of the cargo inside the hollow structure provides a physical protection from the surrounding environment. Here, silver-containing silica nanorattles (Ag@SiO2) were evaluated for their antimicrobial potential and for their impact on cells of the immune system. We show that Ag@SiO2 nanorattles exhibited a clear antibacterial effect against Escherichia coli as well as Staphylococcus aureus found in post-operative infections. Immunotoxicological analyses showed that the particles were taken up through an active phagocytic process by dendritic cells of the immune system and did not affect their viability nor induce unwanted immunological effects. Silver-containing silica nanorattles thus fulfill several prerequisites for an antibacterial coating on surgical implants.