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The HIV-1 Entry Process: A Stoichiometric View

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Brandenberg Oliver F., Magnus Carsten, Regoes Roland R., Trkola Alexandra,
Project The role of humoral immunity in HIV infection - Understanding broadly neutralizing antibody evolution
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Original article (peer-reviewed)

Journal Trends in Microbiology
Volume (Issue) 23(12)
Page(s) 763 - 774
Title of proceedings Trends in Microbiology
DOI 10.1016/j.tim.2015.09.003

Abstract

HIV-1 infection starts with fusion of the viral and the host cell membranes, a process mediated by the HIV-1 envelope glycoprotein trimer. The number of trimers required to complete membrane fusion, referred to as HIV-1 entry stoichiometry, remains under debate. A precise definition of HIV-1 entry stoichiometry is important as it reflects the efficacy of the viral entry process and steers the infectivity of HIV-1 virion populations. Initial estimates suggested a unanimous entry stoichiometry across HIV-1 strains while recent findings showed that HIV-1 strains can differ in entry stoichiometry. Here, we review current analyses of HIV-1 entry stoichiometry and point out future research directions to further define the interplay between entry stoichiometry, virus entry fitness, transmission, and susceptibility to antibody neutralization.
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