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Population genomic analysis of Aegilops tauschii identifies targets for bread wheat improvement

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Gaurav Kumar, Arora Sanu, Silva Paula, Sánchez-Martín Javier, Horsnell Richard, Gao Liangliang, Brar Gurcharn S., Widrig Victoria, John Raupp W., Singh Narinder, Wu Shuangye, Kale Sandip M., Chinoy Catherine, Nicholson Paul, Quiroz-Chávez Jesús, Simmonds James, Hayta Sadiye, Smedley Mark A., Harwood Wendy, Pearce Suzannah, Gilbert David, Kangara Ngonidzashe, Gardener Catherine, Forner-Martínez Macarena, Liu Jiaqian, Yu Guotai, Boden Scott A., Pascucci Attilio, Ghosh Sreya, Hafeez Amber N., O'Hara Tom, Waites Joshua, Cheema Jitender, Steuernagel Burkhard, Patpour Mehran, Justesen Annemarie Fejer, Liu Shuyu, Rudd Jackie C., Avni Raz, Sharon Amir, Steiner Barbara, Kirana Rizky Pasthika, Buerstmayr Hermann, Mehrabi Ali A., Nasyrova Firuza Y., Chayut Noam, Matny Oadi, Steffenson Brian J., Sandhu Nitika, Chhuneja Parveen, Lagudah Evans, Elkot Ahmed F., Tyrrell Simon, Bian Xingdong, Davey Robert P., Simonsen Martin, Schauser Leif, Tiwari Vijay K., Randy Kutcher H., Hucl Pierre, Li Aili, Liu Deng Cai, Mao Long, Xu Steven, Brown-Guedira Gina, Faris Justin, Dvorak Jan, Luo Ming Cheng, Krasileva Ksenia, Lux Thomas, Artmeier Susanne, Mayer Klaus F.X., Uauy Cristobal, Mascher Martin, Bentley Alison R., Keller Beat, Poland Jesse, Wulff Brande B.H.,
Project Molecular analysis of disease resistance specificity in cereals
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Original article (peer-reviewed)

Journal Nature Biotechnology
Page(s) 1 - 27
Title of proceedings Nature Biotechnology
DOI 10.1038/s41587-021-01058-4

Open Access

URL https://www.nature.com/articles/s41587-021-01058-4
Type of Open Access Publisher (Gold Open Access)

Abstract

Aegilops tauschii, the diploid wild progenitor of the D subgenome of bread wheat, is a reservoir of genetic diversity for improving bread wheat performance and environmental resilience. Here we sequenced 242 Ae. tauschii accessions and compared them to the wheat D subgenome to characterize genomic diversity. We found that a rare lineage of Ae. tauschii geographically restricted to present-day Georgia contributed to the wheat D subgenome in the independent hybridizations that gave rise to modern bread wheat. Through k-mer-based association mapping, we identified discrete genomic regions with candidate genes for disease and pest resistance and demonstrated their functional transfer into wheat by transgenesis and wide crossing, including the generation of a library of hexaploids incorporating diverse Ae. tauschii genomes. Exploiting the genomic diversity of the Ae. tauschii ancestral diploid genome permits rapid trait discovery and functional genetic validation in a hexaploid background amenable to breeding.
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