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Current in vitro approaches to assess nanoparticle interactions with lung cells.

Type of publication Peer-reviewed
Publikationsform Review article (peer-reviewed)
Author Fytianos Kleanthis, Drasler Barbara, Blank Fabian, von Garnier Christophe, Seydoux Emilie, Rodriguez-Lorenzo Laura, Petri-Fink Alke, Rothen-Rutishauser Barbara,
Project Biomedical nanoparticles as immune-modulators
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Review article (peer-reviewed)

Journal Nanomedicine (Lond).
Volume (Issue) 11(18)
Page(s) 2457 - 2469
Title of proceedings Nanomedicine (Lond).
DOI 10.2217/nnm-2016-0199

Abstract

The respiratory tract is in constant contact with inhaled antigens from the external environment. In order to shape its line of defense, it is populated by various types of immune cells. Taking into account the scientific breakthroughs of nanomedicine and nanoparticle drug delivery, we can think of the respiratory tract as an ideal target organ to study and develop nanocarrier-based vaccines to treat respiratory tract disorders. Nanoparticles have been proven capable of specific cell targeting and, when suitably engineered, are able to induce an immunomodulatory effect. The aim of this review is to highlight in vitro approaches to the study of nanoparticle-lung immune cell interactions and recent advances in the targeting of immune cells using nanoparticle-based systems.
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