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Bilayer properties of 1,3-diamidophospholipids.

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Publication date 2015
Author Weinberger Andreas, Tanasescu Radu, Stefaniu Cristina, Fedotenko Lllya A, Favarger France, Ishikawa Takashi, Brezesinski Gerald, Marques Carlos M, Zumbuehl Andreas,
Project Approaches for Non-spherical and Surface Activated Liposomes
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Original article (peer-reviewed)

Journal Langmuir : the ACS journal of surfaces and colloids
Volume (Issue) 31(6)
Page(s) 1879 - 84
Title of proceedings Langmuir : the ACS journal of surfaces and colloids
DOI 10.1021/la5041745


A series of 1,3-diamido phosphocholines was synthesized, and their potential to form stable bilayers was investigated. Large and giant unilamellar vesicles produced from these new lipids form a wide variety of faceted liposomes. Factors such as cooling rates and the careful choice of the liposome preparation method influence the formation of facets. Interdigitation was hypothesized as a main factor for the stabilization of facets and effectively monitored by small-angle X-ray scattering measurements.