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Vitamin B6 biosynthesis: charting the mechanistic landscape.

Type of publication Peer-reviewed
Publikationsform Review article (peer-reviewed)
Author Fitzpatrick Teresa B, Moccand Cyril, Roux Céline,
Project Defining vitamin B1 and B6 metabolism in plants: synthesis, regulation and transport
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Review article (peer-reviewed)

Journal Chembiochem : a European journal of chemical biology
Volume (Issue) 11(9)
Page(s) 1185 - 93
Title of proceedings Chembiochem : a European journal of chemical biology
DOI 10.1002/cbic.201000084


Enzyme of the rings: Vitamin B6 biosynthesis through the DXP-independent route is catalyzed by PLP synthase. The enzyme utilizes ribose 5-phosphate, glyceraldehyde 3-phosphate and ammonia to synthesize the cofactor form of the vitamin, pyridoxal 5′-phosphate (PLP). This review provides the emerging mechanistic details of this remarkable Pdx1:Pdx2 glutamine amidotransferase complex.