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Ultra-fast Ligand Self-Exchanging Gadolinium Complexes in Ionic Liquids for NMR Field Probes

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Looser Anna Christina, Barmet Christoph, FoxThomas, Blacque Olivier, Gross Simon, Nussbaum Jennifer, Prüssmann Klaas, Alberto Roger,
Project Homo-Fluorinated Paramagnetic Metal Complexes and Ionic Liquids for the Application in MRI Field Probe Devices
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Original article (peer-reviewed)

Journal Inorganic Chemistry
Title of proceedings Inorganic Chemistry
DOI 10.1021/acs.inorgchem.7b03191

Abstract

Concurrent magnetic field monitoring in MRI with an array of NMR field probes allows for reducing image imperfections. High 19F concentrations together with short relaxation times are basic probe properties. We present the NMR properties of [Gd(NTf2)4]- dissolved in an ionic liquid consisting of an imidazolium cation and the [NTf2]- anion. These solutions achieve fluorine concentrations as high as 26M and rapid relaxation times in the sub-msec range. The 2nd order self-exchange rate of coordinated [NTf2]- with [NTf2]- as determined with [Y(NTf2)4]- is 4.5105M-1s-1. X-ray structure analyses confirm the coordination number of eight around Gd3+ and Y3+. These ionic liquid solutions are thus excellent candidates for dynamically probing the NMR fields in MRI.
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