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Linker histones are fine-scale chromatin architects modulating developmental decisions in Arabidopsis

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Rutowicz Kinga, Lirski Maciej, Mermaz Benoît, Teano Gianluca, Schubert Jasmin, Mestiri Imen, Kroteń Magdalena A., Fabrice Tohnyui Ndinyanka, Fritz Simon, Grob Stefan, Ringli Christoph, Cherkezyan Lusik, Barneche Fredy, Jerzmanowski Andrzej, Baroux Célia,
Project Mechanisms and role of linker histones dynamics in plant reproduction
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Original article (peer-reviewed)

Journal Genome Biology
Volume (Issue) 20(1)
Page(s) 157 - 157
Title of proceedings Genome Biology
DOI 10.1186/s13059-019-1767-3

Open Access

URL http://doi.org/10.1186/s13059-019-1767-3
Type of Open Access Publisher (Gold Open Access)

Abstract

Chromatin in eukaryotes provides a tunable platform to control gene expression and convey an epigenetic memory throughout cell divisions. H1 linker histones are abundant components with an intrinsic potential in influencing chromatin structure and function. We detail the impact of H1 depletion in Arabidopsis on fine-scale chromatin organization, transcription and development. While required for chromocenter assembly, H1s are dispensable for transposable element (TE) silencing and peripheral positioning of heterochromatin. In euchromatin, H1 regulates nucleosome density, mobility, and regular distribution of nanoscale chromatin domains. While necessary to maintain epigenetic patterns, H1 only moderately affects transcription. Its depletion is associated with failures in transitional fate changes such as lateral root initiation, root hair production, stomata patterning but also flowering and dormancy regulation. Therefore, Arabidopsis H1 variants are chromatin architects mediating nano‐ and microscale levels-of-organization operating downstream of epigenetic and transcriptional establishment processes and contribute to epigenetic reorientations in developmental transitions.
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