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Trithorax and Polycomb group-dependent regulation: a tale of opposing activities.

Type of publication Peer-reviewed
Publikationsform Review article (peer-reviewed)
Publication date 2015
Author Geisler Sarah J, Paro Renato,
Project Mechanisms of transcriptional memory in response to developmental and environmental stimuli
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Review article (peer-reviewed)

Journal Development (Cambridge, England)
Volume (Issue) 142(17)
Page(s) 2876 - 87
Title of proceedings Development (Cambridge, England)
DOI 10.1242/dev.120030

Open Access

URL http://dx.doi.org/10.1242/dev.120030
Type of Open Access Publisher (Gold Open Access)

Abstract

Intricate layers of regulation determine the unique gene expression profiles of a given cell and, therefore, underlie the immense phenotypic diversity observed among cell types. Understanding the mechanisms that govern which genes are expressed and which genes are silenced is a fundamental focus in biology. The Polycomb and Trithorax group chromatin proteins play important roles promoting the stable and heritable repression and activation of gene expression, respectively. These proteins, which are conserved across metazoans, modulate post-translational modifications on histone tails and regulate nucleosomal structures. Here, we review recent advances that have shed light on the mechanisms by which these two classes of proteins act to maintain epigenetic memory and allow dynamic switches in gene expression during development.
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