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Specificity of monosynaptic sensory-motor connections imposed by repellent Sema3E-PlexinD1 signaling.

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Publication date 2013
Author Fukuhara Kaori, Imai Fumiyasu, Ladle David R, Katayama Kei-ichi, Leslie Jennifer R, Arber Silvia, Jessell Thomas M, Yoshida Yutaka,
Project Entwicklung und Funktion von motorischen Netzwerken
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Original article (peer-reviewed)

Journal Cell reports
Volume (Issue) 5(3)
Page(s) 748 - 758
Title of proceedings Cell reports
DOI 10.1016/j.celrep.2013.10.005

Open Access

URL http://www.cell.com/cell-reports/pdf/S2211-1247(13)00574-3.pdf
Type of Open Access Publisher (Gold Open Access)

Abstract

In mammalian spinal cord, group Ia proprioceptive afferents form selective monosynaptic connections with a select group of motor pool targets. The extent to which sensory recognition of motor neurons contributes to the selectivity of sensory-motor connections remains unclear. We show here that proprioceptive sensory afferents that express PlexinD1 avoid forming monosynaptic connections with neurons in Sema3E(+) motor pools yet are able to form direct connections with neurons in Sema3E(off) motor pools. Anatomical and electrophysiological analysis of mice in which Sema3E-PlexinD1 signaling has been deregulated or inactivated genetically reveals that repellent signaling underlies aspects of the specificity of monosynaptic sensory-motor connectivity in these reflex arcs. A semaphorin-based system of motor neuron recognition and repulsion therefore contributes to the formation of specific sensory-motor connections in mammalian spinal cord.
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