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Modeling hematopoietic disorders in zebrafish

Type of publication Peer-reviewed
Publikationsform Review article (peer-reviewed)
Author Konantz Martina, Schürch Christoph, Hanns Pauline, Müller Joëlle S., Sauteur Loïc, Lengerke Claudia,
Project Absence of NKG2D ligands on leukemia-initiating cells links stemness to immune evasion
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Review article (peer-reviewed)

Journal Disease Models & Mechanisms
Volume (Issue) 12(9)
Page(s) dmm040360 - dmm040360
Title of proceedings Disease Models & Mechanisms
DOI 10.1242/dmm.040360

Open Access

URL http://doi.org/10.1242/dmm.040360
Type of Open Access Publisher (Gold Open Access)

Abstract

Zebrafish offer a powerful vertebrate model for studies of development and disease. The major advantages of this model include the possibilities of conducting reverse and forward genetic screens and of observing cellular processes by in vivo imaging of single cells. Moreover, pathways regulating blood development are highly conserved between zebrafish and mammals, and several discoveries made in fish were later translated to murine and human models. This review and accompanying poster provide an overview of zebrafish hematopoiesis and discuss the existing zebrafish models of blood disorders, such as myeloid and lymphoid malignancies, bone marrow failure syndromes and immunodeficiencies, with a focus on how these models were generated and how they can be applied for translational research.
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