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Clickosomes - Using triazole-linked phospholipid connectors to fuse vesicles

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Publication date 2012
Author Loosli Frédéric, Doval David Alonso, Grassi David, Zaffalon Pierre Léonard, Favarger France, Zumbuehl Andreas,
Project Approaches for Non-spherical and Surface Activated Liposomes
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Original article (peer-reviewed)

Journal Chemical Communications
Volume (Issue) 48(10)
Page(s) 1604 - 1606
Title of proceedings Chemical Communications
DOI 10.1039/c2cc16827h


Two complementary artificial diether phospholipids were synthesized that can undergo a Cu(i)-catalyzed Huisgen-Sharpless click reaction. The resulting lipid can bridge the membranes of large unilamellar vesicles and cause their aggregation and ultimately their fusion. © 2012 The Royal Society of Chemistry.