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Effects of a short-term overfeeding with fructose or glucose in healthy young males

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Publication date 2010
Author Ngo Sock Emilienne Tudor, Lê Kimanne, Ith Michael, Kreis Roland, Boesch Chris, Tappy Luc,
Project Multi-nuclear magnetic resonance spectroscopy (MRS) and imaging (MRI) on a clinical whole-body MR-system: insulin resistance, ageing, and physical activity
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Original article (peer-reviewed)

Journal British Journal of Nutrition
Volume (Issue) 103(7)
Page(s) 939 - 943
Title of proceedings British Journal of Nutrition
DOI 10.1017/S0007114509992819


Consumption of simple carbohydrates has markedly increased over the past decades, and may be involved in the increased prevalence in metabolic diseases. Whether an increased intake of fructose is specifically related to a dysregulation of glucose and lipid metabolism remains controversial. We therefore compared the effects of hypercaloric diets enriched with fructose (HFrD) or glucose (HGlcD) in healthy men. Eleven subjects were studied in a randomised order after 7d of the following diets: (1) weight maintenance, control diet; (2) HFrD (35g fructose/kg fat-free mass (ffm) per d, +35% energy intake); (3) HGlcD (35g glucose/kg ffm per d, +35% energy intake). Fasting hepatic glucose output (HGO) was measured with 6,6-2H2-glucose. Intrahepatocellular lipids (IHCL) and intramyocellular lipids (IMCL) were measured by 1H magnetic resonance spectroscopy. Both fructose and glucose increased fasting VLDL-TAG (HFrD: +59%, P<005; HGlcD: +31%, P=011) and IHCL (HFrD: +52%, P<005; HGlcD: +58%, P=006). HGO increased after both diets (HFrD: +5%, P<005; HGlcD: +5%, P=005). No change was observed in fasting glycaemia, insulin and alanine aminotransferase concentrations. IMCL increased significantly only after the HGlcD (HFrD: +24%, NS; HGlcD: +59%, P<005). IHCL and VLDL-TAG were not different between hypercaloric HFrD and HGlcD, but were increased compared to values observed with a weight maintenance diet. However, glucose led to a higher increase in IMCL than fructose. Copyright © The Authors 2010.