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Risk factors for treatment failure in orthopedic device-related methicillin-resistant Staphylococcus aureus infection.

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Ferry T, Uçkay I, Vaudaux P, François P, Schrenzel J, Harbarth S, Laurent F, Bernard L, Vandenesch F, Etienne J, Hoffmeyer P, Lew D,
Project Mécanismes moléculaires de la resistance intermédiaire aux glycopeptides chez les staphyloques dorés
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Original article (peer-reviewed)

Journal European journal of clinical microbiology & infectious diseases : official publication of the Europe
Volume (Issue) 29(2)
Page(s) 171 - 80
Title of proceedings European journal of clinical microbiology & infectious diseases : official publication of the Europe
DOI 10.1007/s10096-009-0837-y

Abstract

The purpose of this study was to determine the clinical and microbiological risk factors for treatment failure of methicillin-resistant Staphylococcus aureus (MRSA) orthopedic device-related infection (ODRI). A retrospective cohort study of patients with MRSA ODRI who were treated at Geneva University Hospitals between 2000 and 2008 was undertaken. Stored MRSA isolates were retrieved for genetic characterization and determination of the vancomycin minimum inhibitory concentration (MIC). Fifty-two patients were included, of whom 23 (44%) had joint arthroplasty and 29 (56%) had osteosynthesis. All 41 of the retrieved MRSA isolates were susceptible to vancomycin (MIC
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