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Functionalization of Block Copolymer Vesicle Surfaces

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Publication date 2011
Author Egli S., Schlaad H., Bruns N., Meier W.,
Project Nanostructured Polymers
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Original article (peer-reviewed)

Journal Polymers
Volume (Issue) 3(1)
Page(s) 252 - 280
Title of proceedings Polymers
DOI 10.3390/polym3010252

Open Access

URL http://www.mdpi.com/2073-4360/3/1/252/
Type of Open Access Website

Abstract

In dilute aqueous solutions certain amphiphilic block copolymers self-assemble into vesicles that enclose a small pool of water with a membrane. Such polymersomes have promising applications ranging from targeted drug-delivery devices, to biosensors, and nanoreactors. Interactions between block copolymer membranes and their surroundings are important factors that determine their potential biomedical applications. Such interactions are influenced predominantly by the membrane surface. We review methods to functionalize block copolymer vesicle surfaces by chemical means with ligands such as antibodies, adhesion moieties, enzymes, carbohydrates and fluorophores. Furthermore, surface-functionalization can be achieved by self-assembly of polymers that carry ligands at their chain ends or in their hydrophilic blocks. While this review focuses on the strategies to functionalize vesicle surfaces, the applications realized by, and envisioned for, such functional polymersomes are also highlighted.
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