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Nuclear myocardial perfusion imaging with a novel cadmium-zinc-telluride detector SPECT/CT device: first validation versus invasive coronary angiography.

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Publication date 2011
Author Fiechter Michael, Ghadri Jelena R, Kuest Silke M, Pazhenkottil Aju P, Wolfrum Mathias, Nkoulou Rene N, Goetti Robert, Gaemperli Oliver, Kaufmann Philipp A, Gaemperli Oliver, Templin Christian, Kaufmann Philipp A,
Project Entwicklung einer neuen Hybrid-Bildgebungs-Methode zur nicht invasiven kardialen Diagnostik
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Original article (peer-reviewed)

Journal European journal of nuclear medicine and molecular imaging
Volume (Issue) 38(11)
Page(s) 2025 - 30
Title of proceedings European journal of nuclear medicine and molecular imaging
DOI 10.1007/s00259-011-1877-y


PURPOSE We evaluated the diagnostic accuracy of attenuation corrected nuclear myocardial perfusion imaging (MPI) with a novel hybrid single photon emission computed tomography (SPECT)/CT device consisting of an ultrafast dedicated cardiac gamma camera with cadmium-zinc-telluride (CZT) solid-state semiconductor detectors integrated onto a multislice CT scanner to detect coronary artery disease (CAD). Invasive coronary angiography served as the standard of reference. METHODS The study population included 66 patients (79% men; mean age 63 ± 11 years) who underwent 1-day (99m)Tc-tetrofosmin pharmacological stress/rest examination and angiography within 3 months. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) as well as accuracy of the CT X-ray based attenuation corrected CZT MPI for detection of CAD (≥ 50% luminal narrowing) was calculated on a per-patient basis. RESULTS The prevalence of angiographic CAD in the study population was 82%. Sensitivity, specificity, PPV, NPV and accuracy were 87, 67, 92, 53 and 83%, respectively. CONCLUSION In this first report on CZT SPECT/CT MPI comparison versus angiography we confirm a high accuracy for detection of angiographically documented CAD.