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Searching for targets for the systemic therapy of mesothelioma.

Type of publication Peer-reviewed
Publikationsform Review article (peer-reviewed)
Author Stahel R A, Weder W, Felley-Bosco E, Petrausch U, Curioni-Fontecedro A, Schmitt-Opitz I, Peters S,
Project From asbestos-exposure to cancer: a systemic approach to detect loss of homeostatic control in the mesothelial environment
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Review article (peer-reviewed)

Journal Annals of oncology : official journal of the European Society for Medical Oncology / ESMO
Volume (Issue) 26(8)
Page(s) 1649 - 60
Title of proceedings Annals of oncology : official journal of the European Society for Medical Oncology / ESMO
DOI 10.1093/annonc/mdv101

Abstract

Malignant mesothelioma is an incurable disease associated with asbestos exposure arising in the pleural cavity and less frequently in the peritoneal cavity. Platinum-based combination chemotherapy with pemetrexed is the established standard of care. Multimodality approaches including surgery and radiotherapy are being investigated. Increasing knowledge about the molecular characteristics of mesothelioma had led to the identification of novel potential targets for systemic therapy. Current evidence suggests pathways activated in response to merlin deficiency, including Pi3K/mTOR and the focal adhesion kinase, as well as immunotherapeutic approaches to be most promising. This review elaborates on the rationale behind targeted approaches that have been and are undergoing exploration in mesothelioma and summarizes available clinical results and ongoing efforts to improve the systemic therapy of mesothelioma.
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