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Exome sequencing of healthy phenotypic extremes links TROVE2 to emotional memory and PTSD

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Heck Angela, Milnik Annette, Vukojevic Vanja, Petrovska Jana, Egli Tobias, Singer Jochen, Escobar Pablo, Sengstag Thierry, Coynel David, Freytag Virginie, Fastenrath Matthias, Demougin Philippe, Loos Eva, Hartmann Francina, Schicktanz Nathalie, Delarue Bizzini Bernardo, Vogler Christian, Kolassa Iris-Tatjana, Wilker Sarah, Elbert Thomas, Schwede Torsten, Beisel Christian, Beerenwinkel Niko, de Quervain Dominique J.-F., et al. ,
Project The role of epigenetic modification of glucocorticoid-related genes in aversive memory and post-traumatic stress disorder
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Original article (peer-reviewed)

Journal Nature Human Behaviour
Volume (Issue) 1(4)
Page(s) 0081 - 0081
Title of proceedings Nature Human Behaviour
DOI 10.1038/s41562-017-0081

Open Access


Many mental disorders represent the extremes of the normal distribution of traits, which are related to multiple cognitive and emotional dimensions. By performing whole-exome sequencing of healthy, young subjects with extremely high versus extremely low aversive memory performance, we identified TROVE2 as a gene implicated in emotional memory in health and disease. TROVE2 encodes Ro60, a broadly expressed RNA-binding protein implicated in the regulation of inflammatory gene expression and autoimmunity. A regulatory TROVE2 variant was linked to higher emotional memory capacity and higher emotional memory-related brain activation in healthy subjects. In addition, TROVE2 was associated with traumatic memory and the frequency of post-traumatic stress disorder in genocide survivors.