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Effects of alpha interferon treatment on intrinsic anti-HIV-1 immunity in vivo.

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Abdel-Mohsen Mohamed, Deng Xutao, Liegler Teri, Guatelli John C, Salama Mohamed S, Ghanem Hussam El-din A, Rauch Andri, Ledergerber Bruno, Deeks Steven G, Günthard Huldrych F, Wong Joseph K, Pillai Satish K,
Project Swiss HIV Cohort Study (SHCS)
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Original article (peer-reviewed)

Journal Journal of virology
Volume (Issue) 88(1)
Page(s) 763 - 7
Title of proceedings Journal of virology
DOI 10.1128/jvi.02687-13

Open Access

URL http://doi.org/10.1128/JVI.02687-13
Type of Open Access Publisher (Gold Open Access)

Abstract

Alpha interferon (IFN-α) suppresses human immunodeficiency virus type 1 (HIV-1) replication in vitro by inducing cell-intrinsic retroviral restriction mechanisms. We investigated the effects of IFN-α/ribavirin (IFN-α/riba) treatment on 34 anti-HIV-1 restriction factors in vivo. Expression of several anti-HIV-1 restriction factors was significantly induced by IFN-α/riba in HIV/hepatitis C virus (HCV)-coinfected individuals. Fold induction of cumulative restriction factor expression in CD4(+) T cells was significantly correlated with viral load reduction during IFN-α/riba treatment (r(2) = 0.649; P < 0.016). Exogenous IFN-α induces supraphysiologic restriction factor expression associated with a pronounced decrease in HIV-1 viremia.
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