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Comparison of tigecycline and vancomycin for treatment of experimental foreign-body infection due to methicillin-resistant Staphylococcus aureus.

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Vaudaux Pierre, Fleury Bénédicte, Gjinovci Asllan, Huggler Elzbieta, Tangomo-Bento Manuela, Lew Daniel P,
Project Mécanismes moléculaires de la resistance intermédiaire aux glycopeptides chez les staphyloques dorés
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Original article (peer-reviewed)

Journal Antimicrobial agents and chemotherapy
Volume (Issue) 53(7)
Page(s) 3150 - 2
Title of proceedings Antimicrobial agents and chemotherapy
DOI 10.1128/AAC.01612-08

Abstract

Twice-daily 7-day regimens of tigecycline (7 mg/kg) and vancomycin (50 mg/kg) were compared in a rat tissue cage model of chronic foreign-body infection due to methicillin (meticillin)-resistant Staphylococcus aureus strain MRGR3. Subcutaneously administered tigecycline reached levels in tissue cage fluid that were nearly equivalent or slightly superior to the antibiotic MIC (0.5 microg/ml) for strain MRGR3. After 7 days, equivalent, significant reductions in bacterial counts were recorded for tigecycline-treated and vancomycin-treated rats, compared with those for untreated animals.
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