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Intramyocellular lipid variations in active older men: relationship with aerobic fitness.

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Publication date 2012
Author Rouffet David, Villars Clément, Fissoune Rachida, Sappey-Marinier Dominique, Laville Martine, Ibarrola Danielle, Sothier Monique, Monnet Marie-France, Ovize Michel, Bonnefoy Marc, Boesch Chris, Canet-Soulas Emmanuelle,
Project Multi-nuclear magnetic resonance spectroscopy (MRS) and imaging (MRI) on a clinical whole-body MR-system: insulin resistance, ageing, and physical activity
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Original article (peer-reviewed)

Journal Acta physiologica (Oxford, England)
Volume (Issue) [Epub ahead of print](N/A)
Page(s) N/A - N/A
Title of proceedings Acta physiologica (Oxford, England)
DOI 10.1111/apha.12045

Abstract

AIMS: Intramyocellular lipids (IMCL) variations in older men are poorly explored. In young adults, IMCL can be influenced both by diet and exercise interventions; this flexibility is related to aerobic fitness. We evaluated in active older adults, the influence of maximal aerobic capacity on short-term diet and exercise-induced variations in IMCL stores. METHODS: IMCL were measured by (1) H magnetic resonance spectroscopy ((1) H-MRS) after a 3-day fat depletion-replenishment diet (IMCL(FDR) ) and immediately after a 2-hour exercise at 50% VO(2) max (IMCL(FDR_EX) ). To further explore diet influence, the protocol was repeated after a high fat diet (HF), with both pre and post exercise measurements (IMCL(HF) and IMCL(HF_EX) ). RESULTS: In active older men (69.8±5.2 years), IMCL(FDR) were lowered by exercise (IMCL(FDR) = 3.45±1.52 vs. IMCL(FDR_EX) =2.74±1.15 mmol kg(-1) wet weight, p<0.05), and exercise-induced variations were correlated to the initial store (p<0.05, r=-0.72). IMCL(FDR) were linked with aerobic fitness (p<0.05, r=0.76), when adjusted by fat mass. IMCL(HF) were lower than IMCL(FDR) (p<0.05), decreased after exercise (p<0.05), and varied also as a function of initial store (p<0.05, r=-0.89), but without link with aerobic fitness. Finally, diet-induced IMCL store variations was positively linked to aerobic fitness (p<0.05, r=0.89). CONCLUSION: Variations of the IMCL stores in physically active older adults appears related to aerobic fitness, with similarly fast adaptation to short-term interventions combining diet and exercise as young active adults. © 2012 The Authors Acta Physiologica © 2012 Scandinavian Physiological Society.
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