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Host genetics and HIV-1: the final phase?

Type of publication Peer-reviewed
Publikationsform Review article (peer-reviewed)
Publication date 2010
Author Fellay Jacques, Shianna Kevin V, Telenti Amalio, Goldstein David B,
Project Host evolutionary genomics of HIV-1 and other retroviruses
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Review article (peer-reviewed)

Journal PLoS pathogens
Volume (Issue) 6(10)
Page(s) 1001033 - 1001033
Title of proceedings PLoS pathogens
DOI 10.1371/journal.ppat.1001033


This is a crucial transition time for human genetics in general, and for HIV host genetics in particular. After years of equivocal results from candidate gene analyses, several genome-wide association studies have been published that looked at plasma viral load or disease progression. Results from other studies that used various large-scale approaches (siRNA screens, transcriptome or proteome analysis, comparative genomics) have also shed new light on retroviral pathogenesis. However, most of the inter-individual variability in response to HIV-1 infection remains to be explained: genome resequencing and systems biology approaches are now required to progress toward a better understanding of the complex interactions between HIV-1 and its human host.