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Multi-scale optoacoustic molecular imaging of brain diseases

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Razansky Daniel, Klohs Jan, Ni Ruiqing,
Project Investigating the effects of hypercholesterolemia on neutrophil-mediated thromboinflammation after cerebral ischemia
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Original article (peer-reviewed)

Journal European Journal of Nuclear Medicine and Molecular Imaging
Page(s) 200
Title of proceedings European Journal of Nuclear Medicine and Molecular Imaging
DOI 10.1007/s00259-021-05207-4

Open Access

URL http://doi.org/10.1007/s00259-021-05207-4
Type of Open Access Publisher (Gold Open Access)

Abstract

AbstractThe ability to non-invasively visualize endogenous chromophores and exogenous probes and sensors across the entire rodent brain with the high spatial and temporal resolution has empowered optoacoustic imaging modalities with unprecedented capacities for interrogating the brain under physiological and diseased conditions. This has rapidly transformed optoacoustic microscopy (OAM) and multi-spectral optoacoustic tomography (MSOT) into emerging research tools to study animal models of brain diseases. In this review, we describe the principles of optoacoustic imaging and showcase recent technical advances that enable high-resolution real-time brain observations in preclinical models. In addition, advanced molecular probe designs allow for efficient visualization of pathophysiological processes playing a central role in a variety of neurodegenerative diseases, brain tumors, and stroke. We describe outstanding challenges in optoacoustic imaging methodologies and propose a future outlook.
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