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Correlating HIV tropism with immunological response under combination antiretroviral therapy.

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Bader J, Schöni-Affolter F, Böni J, Gorgievski-Hrisoho M, Martinetti G, Battegay M, Klimkait T,
Project Swiss HIV Cohort Study (SHCS)
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Original article (peer-reviewed)

Journal HIV medicine
Page(s) 615 - 22
Title of proceedings HIV medicine
DOI 10.1111/hiv.12365

Open Access

URL https://onlinelibrary.wiley.com/doi/full/10.1111/hiv.12365
Type of Open Access Repository (Green Open Access)

Abstract

A significant percentage of patients infected with HIV-1 experience only suboptimal CD4 cell recovery while treated with combination therapy (cART). It is still unclear whether viral properties such as cell tropism play a major role in this incomplete immune response. This study therefore intended to follow the tropism evolution of the HIV-1 envelope during periods of suppressive cART. Viruses from two distinct patient groups, one with good and another one with poor CD4 recovery after 5 years of suppressive cART, were genotypically analysed for viral tropism at baseline and at the end of the study period. Patients with CCR5-tropic CC-motif chemokine receptor 5 viruses at baseline tended to maintain this tropism to the study end. Patients who had a CXCR4-tropic CXC-motif chemokine receptor 4 virus at baseline were overrepresented in the poor CD4 recovery group. Overall, however, the majority of patients presented with CCR5-tropic viruses at follow-up. Our data lend support to the hypothesis that tropism determination can be used as a parameter for disease progression even if analysed long before the establishment of a poorer immune response. Moreover, the lasting predominating CCR5-tropism during periods of full viral control suggests the involvement of cellular mechanisms that preferentially reduce CXCR4-tropic viruses during cART.
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