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Gut-associated microbes of Drosophila melanogaster

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Publication date 2012
Author Broderick N.A., Lemaitre B,
Project The Drosophila intestinal epithelium: an immune barrier
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Original article (peer-reviewed)

Journal Gut Microbes
Volume (Issue) 3:4
Page(s) 1 - 16
Title of proceedings Gut Microbes
DOI http://dx.doi.org/10.4161/gmic.19896

Abstract

There is growing interest in using Drosophila melanogaster to elucidate mechanisms that underlie the complex relationships between a host and its microbiota. In addition to the many genetic resources and tools Drosophila provides, its associated microbiota is relatively simple (1–30 taxa), in contrast to the complex diversity associated with vertebrates (>500 taxa). These attributes highlight the potential of this system to dissect the complex cellular and molecular interactions that occur between a host and its microbiota. In this review, we summarize what is known regarding the composition of gutassociated microbes of Drosophila and their impact on host physiology. We also discuss these interactions in the context of their natural history and ecology and describe some recent insights into mechanisms by which Drosophila and its gut microbiota interact.
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