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Chemical synthesis of mono- and bis-labeled pre-MicroRNAs

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Publication date 2013
Author Pradère Ugo, Brunschweiger Andreas, Gebert Luca F R, Lucic Matije, Roos Martina, Hall Jonathan,
Project Post-transcriptional regulation of germ cell apoptosis in C. elegans
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Original article (peer-reviewed)

Journal Angewandte Chemie - International Edition
Volume (Issue) 52(46)
Page(s) 12028 - 12032
Title of proceedings Angewandte Chemie - International Edition
DOI 10.1002/anie.201304986

Abstract

A chemical method for the post-synthetic labeling of pre-miRNAs on solid support using easily accessible reagents was developed. The procedure was employed to generate a library of 31 pre-microRNAs carrying labels commonly used in chemical biology, including Cy3, trioxalen, biotin, and BHQ-1. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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