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Lactate dehydrogenase concentration in nasal wash fluid indicates severity of rhinovirus-induced wheezy bronchitis in preschool children.

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Cangiano Giulia, Proietti Elena, Kronig Marie Noelle, Kieninger Elisabeth, Sadeghi Christine D, Gorgievski Meri, Barbani Maria Teresa, Midulla Fabio, Tapparel Caroline, Kaiser Laurent, Alves Marco P, Regamey Nicolas, Cangiano Giulia, Proietti Elena, Kronig Marie Noelle, Kieninger Elisabeth, Sadeghi Christine D, Gorgievski Meri, Barbani Maria Teresa, Midulla Fabio, Tapparel Caroline, Kaiser Laurent, Alves Marco P, Regamey Nicolas,
Project Rhinovirus et entérovirus: déterminants génomiques et phénotypes associés
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Original article (peer-reviewed)

Journal The Pediatric infectious disease journal
Volume (Issue) 33(12)
Page(s) 1285 - 7
Title of proceedings The Pediatric infectious disease journal
DOI 10.1097/inf.0000000000000420

Open Access

Abstract

The clinical course of rhinovirus (RV)-associated wheezing illnesses is difficult to predict. We measured lactate dehydrogenase concentrations, RV load, antiviral and proinflammatory cytokines in nasal washes obtained from 126 preschool children with RV wheezy bronchitis. lactate dehydrogenase values were inversely associated with subsequent need for oxygen therapy. lactate dehydrogenase may be a useful biomarker predicting disease severity in RV wheezy bronchitis.
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