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In vitro-ex vivo model systems for nanosafety assessment

Type of publication Peer-reviewed
Publikationsform Review article (peer-reviewed)
Author Peter Wick, Savvina Chortarea, Olivier Guenat, Matthias Roesslein, Janick Stucki, Alke Petri-Fink, Barbara Rothen-Rutishauser,
Project Biomedical nanoparticles as immune-modulators
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Review article (peer-reviewed)

Journal Eur J Nanomed
Volume (Issue) 7(3)
Page(s) 169 - 179
Title of proceedings Eur J Nanomed

Open Access

Abstract

Engineered nanomaterials have unique and novel properties enabling many new applications in nearly all fields of research. Since these new properties have raised concerns about potential adverse effects for environment and human health many efforts are undertaken to define reliable, cost and time effective, rapid and mechanistic based testing strategies to replace current animal testing which is still the most prevalent model used for risk assessment of nanomaterials. The aim of this review is to explore and qualify the relevance of new in vitro and ex vivo models in (nano)material functionality and safety assessment which is a pre-requisite for translation into applications.
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