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Phylogeny-based systematization of arabidopsis proteins with histone H1 globular domain

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Kotlinski M., Knizewski L., Muszewska A., Rutowicz K., Lirski M., Schmidt A., Baroux C., Ginalski K., Jerzmanowski A.,
Project Mechanisms and role of linker histones dynamics in plant reproduction
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Original article (peer-reviewed)

Journal Plant Physiology
Volume (Issue) 174(1)
Page(s) 27 - 34
Title of proceedings Plant Physiology
DOI 10.1104/pp.16.00214


H1 (or linker) histones are basic nuclear proteins that possess an evolutionarily conserved nucleosome-binding globular domain, GH1. They perform critical functions in determining the accessibility of chromatin DNA to trans-acting factors. In most metazoan species studied so far, linker histones are highly heterogenous, with numerous nonallelic variants cooccurring in the same cells. The phylogenetic relationships among these variants as well as their structural and functional properties have been relatively well established. This contrasts markedly with the rather limited knowledge concerning the phylogeny and structural and functional roles of an unusually diverse group of GH1-containing proteins in plants. The dearth of information and the lack of a coherent phylogeny-based nomenclature of these proteins can lead to misunderstandings regarding their identity and possible relationships, thereby hampering plant chromatin research. Based on published data and our in silico and highthroughput analyses, we propose a systematization and coherent nomenclature of GH1-containing proteins of Arabidopsis (Arabidopsis thaliana [L.] Heynh) that will be useful for both the identification and structural and functional characterization of homologous proteins from other plant species.