Back to overview

Dissecting the activation of insulin degrading enzyme by inositol pyrophosphates and their bisphosphonate analogs

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Hostachy Sarah, Utesch Tillmann, Franke Katy, Dornan Gillian Leigh, Furkert David, Türkaydin Berke, Haucke Volker, Sun Han, Fiedler Dorothea,
Project Discovery and mechanistic dissection of novel signaling pathways controlling phosphate homeostasis in eukaryotes
Show all

Original article (peer-reviewed)

Journal Chemical Science
Page(s) 1 - 10
Title of proceedings Chemical Science
DOI 10.1039/d1sc02975d

Open Access

Type of Open Access Publisher (Gold Open Access)


An efficient synthesis of non-hydrolyzable inositol pyrophosphate analogs was developed to subsequently investigate the regulation of insulin-degrading enzyme by these hyperphosphorylated signaling molecules.