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Dissecting the activation of insulin degrading enzyme by inositol pyrophosphates and their bisphosphonate analogs

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Hostachy Sarah, Utesch Tillmann, Franke Katy, Dornan Gillian Leigh, Furkert David, Türkaydin Berke, Haucke Volker, Sun Han, Fiedler Dorothea,
Project Discovery and mechanistic dissection of novel signaling pathways controlling phosphate homeostasis in eukaryotes
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Original article (peer-reviewed)

Journal Chemical Science
Page(s) 1 - 10
Title of proceedings Chemical Science
DOI 10.1039/d1sc02975d

Open Access

URL http://doi.org/10.1039/D1SC02975D
Type of Open Access Publisher (Gold Open Access)

Abstract

An efficient synthesis of non-hydrolyzable inositol pyrophosphate analogs was developed to subsequently investigate the regulation of insulin-degrading enzyme by these hyperphosphorylated signaling molecules.
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