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3D-Integration of Printed Electrochemical Sensors in PET Microfluidics for Biochemical Sensing

Type of publication Peer-reviewed
Publikationsform Proceedings (peer-reviewed)
Author Demuru Silvia, Haque R., Joho M. O., Bionaz A., van der Wal P., Briand D.,
Project WeCare: Cognitive-Multisensing Wearable Sweat Biomonitoring Technology for Real-Time Personalized Diagnosis and Preventive Health Care
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Proceedings (peer-reviewed)

Title of proceedings Transducers – Eurosensors XXXIII


This paper presents a novel process for screen printed electrode fabrication, functionalization and integration in a polyethylene terephthalate (PET) fluidics system for electrochemical analysis. The innovative components utilized are: 1. 3D Through-Foil Vias (TFVs) for electrode connection, enabling simple liquid tight lamination of micro-fluidic channels; 2. Screen printed carbon and silver/silver chloride (Ag/AgCl) electrodes on 3D vias; and 3. PET fluidics with a fabrication process compatible with large-area manufacturing. A platform integrating an Ag/AgCl pseudo-reference and a glucose oxidase (GOx)-modified working electrode has been used for glucose sensing in the flexible fluidics system. Detection of small glucose concentrations between 100- 400 μM through Cyclic Voltammetry (CV) is shown. The sensor shows linear response and good sensitivity of ~0.8 mA/(mM cm2). By changing the electrode coatings, the same technology can potentially be used for detecting multiple analytes in biofluids.