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Fully Integrated Biochip Platforms for Advanced Healthcare

Type of publication Peer-reviewed
Publikationsform Review article (peer-reviewed)
Author Sandro Carrara Sara Seyedeh Ghoreishizadeh Jacopo Olivo Irene Taurino Camilla Baj-Rossi et al,
Project Innovative Enabling Micro-Nano-Bio-technologies for Implantable systems in molecular medicine and personalized therapy
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Review article (peer-reviewed)

Journal Sensors
Page(s) 11013
Title of proceedings Sensors

Open Access

Type of Open Access Website


Recent advances in microelectronics and biosensors are enabling developments of innovative biochips for advanced healthcare by providing fully integrated platforms for continuous monitoring of a large set of human disease biomarkers. Continuous monitoring of several human metabolites can be addressed by using fully integrated and minimally invasive devices located in the sub-cutis, typically in the peritoneal region. This extends the techniques of continuous monitoring of glucose currently being pursued with diabetic patients. However, several issues have to be considered in order to succeed in developing fully integrated and minimally invasive implantable devices. These innovative devices require a high-degree of integration, minimal invasive surgery, long-term biocompatibility, security and privacy in data transmission, high reliability, high reproducibility, high specificity, low detection limit and high sensitivity. Recent advances in the field have already proposed possible solutions for several of these issues. The aim of the present paper is to present a broad spectrum of recent results and to propose future directions of development in order to obtain fully implantable systems for the continuous monitoring of the human metabolism in advanced healthcare applications