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Role of Sec62 in ER maintenance: a link with ER stress tolerance in SEC62 overexpressing-tumors?

Type of publication Peer-reviewed
Publikationsform Review article (peer-reviewed)
Author Bergmann T.J., Fumagalli F., Loi M., Molinari M.,
Project ER-phagy mechanisms to maintain and restore endoplasmic reticulum homeostasis
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Review article (peer-reviewed)

Journal Molecular and Cellular Oncology
Volume (Issue) 4(2)
Page(s) e1264351
Title of proceedings Molecular and Cellular Oncology
DOI 10.1080/23723556.2016.1264351

Open Access


Amplification of the candidate oncogene TLOC1/SEC62 in tumors correlates with reduced patient survival. The recently reported role of SEC62 as an autophagy receptor that controls endoplasmic reticulum (ER) size and function might open new scenarios for understanding the phenotypes and treat SEC62high tumors, which are characterized by high ER stress tolerance.