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Prognostic value of vitamin D level for all-cause mortality, and association with inflammatory markers, in HIV-infected persons.

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Shepherd Leah, Souberbielle Jean-Claude, Bastard Jean-Philippe, Fellahi Soraya, Capeau Jaqueline, Reekie Joanne, Reiss Peter, Blaxhult Anders, Bickel Markus, Leen Clifford, Kirk Ole, Lundgren Jens D, Mocroft Amanda, Viard Jean-Paul,
Project Swiss HIV Cohort Study (SHCS)
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Original article (peer-reviewed)

Journal The Journal of infectious diseases
Volume (Issue) 210(2)
Page(s) 234 - 43
Title of proceedings The Journal of infectious diseases
DOI 10.1093/infdis/jiu074

Open Access

URL https://doi.org/10.1093/infdis/jiu074
Type of Open Access Publisher (Gold Open Access)

Abstract

Low 25-hydroxyvitamin D (25(OH)D) has been associated with inflammation, human immunodeficiency virus (HIV) disease progression, and death. We aimed to identify the prognostic value of 25(OH)D for AIDS, non-AIDS-defining events and death, and its association with immunological/inflammatory markers. Prospective 1-1 case-control study nested within the EuroSIDA cohort. Matched cases and controls for AIDS (n = 50 matched pairs), non-AIDS-defining (n = 63) events and death (n = 41), with plasma samples during follow-up were selected. Conditional logistic regression models investigated associations between 25(OH)D levels and annual 25(OH)D change and the probability of events. Mixed models investigated relationships between 25(OH)D levels and immunological/inflammatory markers. In sum, 250 patients were included. Median time between first and last sample and last sample and event was 44.6(interquartile range [IQR]: 22.7-72.3) and 3.1(IQR: 1.4-6.4) months. Odds of death decreased by 46.0%(95% confidence interval [CI], 2.0-70.0, P = .04) for a 2-fold increase in latest 25(OH)D level. There was no association between 25(OH)D and the occurrence of AIDS or non-AIDS-defining events (P > .05). In patients with current 25(OH)D <10 ng/mL, hsIL-6 concentration increased by 4.7%(95% CI, .2,9.4, P = .04) annually after adjustment for immunological/inflammatory markers, and no change in hsCRP rate was observed (P = .76). Low Vitamin D predicts short term mortality in HIV-positive persons. Effectiveness of vitamin D supplementation on inflammation and patient outcomes should be investigated.
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