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Synthesis of glycyrrhetinic acid derivatives for the treatment of metabolic diseases.

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Beseda Igor, Czollner Laszlo, Shah Priti S, Khunt Rupesh, Gaware Rawindra, Kosma Paul, Stanetty Christian, Del Ruiz-Ruiz Maria Carmen, Amer Hassan, Mereiter Kurt, Da Cunha Thierry, Odermatt Alex, Classen-Houben Dirk, Jordis Ulrich,
Project The Regulation of Glucocorticoid and Mineralocorticoid Hormone Action by 11beta-Hydroxysteroid Dehydrogenases
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Original article (peer-reviewed)

Journal Bioorganic & medicinal chemistry
Volume (Issue) 18(1)
Page(s) 433 - 54
Title of proceedings Bioorganic & medicinal chemistry
DOI 10.1016/j.bmc.2009.10.036

Abstract

The effect of glycyrrhetinic acid (GA) and GA-derivatives towards 11beta-hydroxysteroid dehydrogenase (11beta-HSD) was investigated. Novel compounds with modifications at positions C-3, C-11 and C-29 of the GA skeleton were prepared. Single crystal X-ray diffraction data of selected substances are reported and discussed.
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