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Cardiac-specific ablation of synapse-associated protein SAP97 in mice decreases potassium currents but not sodium current

Type of publication Peer-reviewed
Publikationsform Original article (peer-reviewed)
Author Gillet L., Rougier Jean-Sebastien, Shy Diana, Sonntag Stephan, Mougenot Nathalie, Essers Maria, Shmerling Doron, Balse Elise, Hatem Stephane N., Abriel Hugues,
Project Molecular Determinants of Nav1.5 Multiprotein Complexes in Cardiac Cells
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Original article (peer-reviewed)

Journal Heart Rhythm
Volume (Issue) 12
Page(s) 181 - 192
Title of proceedings Heart Rhythm


Background Membrane-associated guanylate kinase (MAGUK) proteins are important determinants of ion channel organization in the plasma membrane. In the heart, the MAGUK protein SAP97, encoded by the DLG1 gene, interacts with several ion channels via their PDZ domain-binding motif and regulates their function and localization. Objective The purpose of this study was to assess in vivo the role of SAP97 in the heart by generating a genetically modified mouse model in which SAP97 is suppressed exclusively in cardiomyocytes. Methods SAP97fl/fl mice were generated by inserting loxP sequences flanking exons 1