Lay summary

In the last few years, our group has studied and developed new anticancer drugs that contain are effective against primary tumours and metastasis where classical drugs such as cisplatin and other related drugs are ineffective. The biomolecular interactions of most drugs, from intravenous application to delivery to the cell and entry into specific organelles such as the nucleus, are largely unknown. This project aims to clarify the ambiguity surrounding these by mapping the protein-drug interactions that occur inside and outside the cell. The Electrospray Ionisation-Mass Spectrometer (ESI-MS) that we intend to purchase will become the central analytical tool that will allow us to investigate and delineate these processes. Thus, the equipment will be dedicated in the elucidation of the mode of action of drugs in complex biological systems.