Lay summary
This project aims at exploring the genetic bases of vulnerability to behavioral stress and stress-related disorders such as hyperanxiety, post-traumatic stress syndrome and depression. The four groups engaged in tackling this objective will capitalize on their recent discovery that a particular family of so-called epigenetic regulators of gene expression conditions susceptibility to behavioral stress and stress-induced cognitive defects in the mouse, and on their previous development of techniques to identify genetic factors related to emotional and non-emotional memory in humans. The study will combine molecular, genetic, behavioral and neuroimaging appraoches in a truly multidisciplinary atmosphere. The definition of genetic predictors of stress-induced pathologies will help design new approaches for the prevention and treatment of these pandemic diseases.