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Beliefs and expectation effects in health concerns about modern technologies

Applicant Wicht Corentin
Number 181689
Funding scheme Doc.CH
Research institution Département de Médecine Université de Fribourg
Institution of higher education University of Fribourg - FR
Main discipline Psychology
Start/End 01.10.2018 - 31.03.2022
Approved amount 237'382.00
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Keywords (8)

Placebo; Expectations; Caffeine; Morphine; Cognition; Pain; Neuropsychopharmacology; EEG

Lay Summary (French)

Lead
L'effet placebo correspond à un effet bénéfique pour la santé dont le mécanisme d'action est attribué à des facteurs psychologiques. Parmi ces derniers, les attentes formées soit par l'observation soit par la connaissance des effets d'une substance, d'une intervention permettent de générer des effets placebo parfois équivalent à ceux de la substance ou de l'intervention qu'ils reproduisent. Nous nous intéressons à étudier l'effet des attentes par rapport aux effets cognitifs de la caféine et antalgiques de la morphine dans une population saine.
Lay summary

Contenu et objectifs du travail de recherche

Nous cherchons à mieux comprendre les base neurophysiologiques des effets i) cognitifs attribués à la caféine et ii) antalgiques attribués à la morphine. Nous planifions de faire usage de designs spécifiques permettant la distinction entre l’effet purement pharmacologique/physiologique d’une intervention et l’effet psychologique lié aux attentes formées par rapport à ces effets. Notre but est de déterminer si les attentes positives des effets de la caféine sur la cognition et de la morphine sur les douleurs sont attribuables majoritairement à l’action pharmacologique de ces substances ou alors si ces effets sont dus aux attentes (effet placebo).

Contexte scientifique et sociétal du projet

L'effet placebo a été étudié en détails dans le cadre clinique mais très peu de recherches fondamentales se sont intéressées à leurs présences dans la population saine. Puisque les informations véhiculées notamment par les médias sont susceptibles de générer des attentes, il est capital de comprendre l’influence que peuvent avoir, par la suite, ces attentes sur la santé psychologique de la population.

Direct link to Lay Summary Last update: 19.02.2020

Responsible applicant and co-applicants

Employees

Publications

Publication
Experience with opioids does not modify the brain network involved in expectations of placebo analgesia
Wicht Corentin A., Mouthon Michael, Chabwine Joelle Nsimire, Gaab Jens, Spierer Lucas (2022), Experience with opioids does not modify the brain network involved in expectations of placebo analgesia, in European Journal of Neuroscience, 1-19.
Neural correlates of expectations-induced effects of caffeine intake on executive functions
Wicht Corentin A., De Pretto Michael, Mouthon Michael, Spierer Lucas (2022), Neural correlates of expectations-induced effects of caffeine intake on executive functions, in Cortex, 1-24.

Datasets

Neural correlates of expectations-induced effects of caffeine intake on executive functions

Author Wicht, Corentin Aurèle
Publication date 29.04.2021
Persistent Identifier (PID) https://doi.org/10.5281/zenodo.4500849
Repository Zenodo
Abstract
The database contains all raw data used in the Registered Report currently under Stage-2 reviewing at Cortex.

Distinct brain networks involved in placebo analgesia between individuals with or without prior experience with opioids

Author Wicht, Corentin Aurèle
Publication date 06.12.2021
Persistent Identifier (PID) https://doi.org/10.5281/zenodo.5749398
Repository Zenodo
Abstract
The database contains all raw data used in the Registered Report currently under Stage-2 reviewing at European Journal of Neuroscience.

Collaboration

Group / person Country
Types of collaboration
Antalgia Center, CHUV Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
Cognition Day Talk given at a conference The electrophysiological correlates of expectations effects 06.10.2021 Fribourg, Switzerland Wicht Corentin;


Communication with the public

Communication Title Media Place Year
Media relations: radio, television L'effet placebo, un substitut potentiel à la morphine? Frapp Western Switzerland 2022
Video/Film Sola Dosis Western Switzerland 2020

Abstract

Placebo effects (PE) are defined as the beneficial psychophysiological outcomes of an intervention that are not attributable to its inherent properties (Benedetti et al., 2011; Wager and Atlas, 2015). PE thus only result from the administration of the intervention, which is thought to influence psychophysiological state via learning-based expectations about the effects of the actual intervention (Kirsch, 1985; Haour, 2005; Finniss et al., 2010; Benedetti et al., 2011). According to the Expectancy Theory (Kirsch, 1985, 1997), Pavlovian conditioning indeed constitutes one of the main mechanism by which PE-triggering expectations are formed. In such context, classical conditioning has been redefined as the process of learning of relations between events (Robert, 1988). Conditioning, whose fulfillment is based on the information that the conditioned stimulus (CS, e.g. smell, taste, popular knowledge regarding a substance) provides about the unconditioned stimulus (US, the actual substance) and not on contiguity (Kirsch, 1997), will engender expectations that certain events will follow other events ultimately leading to a conditioned pharmacological response (Smart et al., 1983). Yet, while many studies examined the effects of expectations, most of them focused on behavioral or physiological outcomes, leaving largely unresolved the underlying neurophysiological mechanisms (for reviews, see e.g. Benedetti, 2014; Enck et al., 2013; Wager and Atlas, 2015). To investigate the neurocognitive and psychological effects of expectations manipulation we will investigate PE in the contexts of i) caffeine administration and ii) acute pain induction. For that purpose, we will rely on adapted versions of the original Balanced Placebo Design (BPD; Marlatt and Rohsenow, 1980). Initially developed to assess the pure pharmacological effects of psychotropic medications (Ross et al., 1962; Lyerly et al., 1964), this four-cell experimental design also reveals the influence of instruction set and prior knowledge-based expectations in the observed effects. This design consists of a 2 X 2 matrix comprising 4 conditions, namely i) told drug/receive drug, ii) told drug/receive placebo, iii) told placebo/receive drug, iv) told placebo/receive placebo. Consequently, the specificity of the expectancy and of the pharmacological effects are accounted for by conditions i) & ii) and, respectively, by conditions iii) & iv).
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