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State-dependency of inhibitory control plasticity

English title State-dependency of inhibitory control plasticity
Applicant Spierer Lucas
Number 175469
Funding scheme Project funding
Research institution Neurology Unit, Medicine Section Department of Neuroscience and Movement University of Fribourg
Institution of higher education University of Fribourg - FR
Main discipline Neurophysiology and Brain Research
Start/End 01.01.2018 - 30.09.2022
Approved amount 594'408.00
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All Disciplines (2)

Discipline
Neurophysiology and Brain Research
Neurology, Psychiatry

Keywords (5)

Inhibitory control; Brain plasticity; ERP; Lesion; Brain stimulation

Lay Summary (French)

Lead
Le ‘control inhibiteur’ désigne la capacité s'interrompre un processus cognitif ou moteur en cours d'execution. Cette fonction permet notamment de contrôler des réponses impulsives ou inappropriées. Comme le control inhibiteur peut être amélioré par des entraînements, la pratique répétée de tâche impliquant le contrôle inhibiteur pourrait être utilisé en clinique pour la réhabilitation des pertes de contrôle comme il peut se manifester dans l’addiction ou le vieillissement. Cependant, les conditions neurophysiologiques modulant les effets d’entrainement et les mécanismes cérébraux sous-jacents restent peu connus.
Lay summary

Le présent projet vise à explorer comment le vieillissement, la stimulation cérébrale non-invasive et les lésions cérébrales interagissent avec les effets comportementaux et neurophysiologiques des entraînements au control inhibiteur. Ces questions seront adressées avec des essais cliniques randomisés en double aveugle dans lesquels les effet d’entraînements seront évalués avec les mesures comportementales et de neuroimagerie. 

En plus d’apporter des informations fondamentales sur les mécanismes neurophysiologiques de la plasticité cérébrale induite par des entraînements au contrôle inhibiteur, notre projet aura une applicabilité clinique immédiate pour la réhabilitation des déficits du control inhibiteur.

Direct link to Lay Summary Last update: 12.01.2018

Responsible applicant and co-applicants

Employees

Publications

Publication
Aging Modulates Prefrontal Plasticity Induced by Executive Control Training
Najberg Hugo, Wachtl Laura, Anziano Marco, Mouthon Michael, Spierer Lucas (2020), Aging Modulates Prefrontal Plasticity Induced by Executive Control Training, in Cerebral Cortex, 00.
Acute alcohol intoxication and expectations reshape the spatiotemporal functional architecture of executive control
Ribordy Lambert Farfalla, Wicht Corentin A., Mouthon Michael, Spierer Lucas (2020), Acute alcohol intoxication and expectations reshape the spatiotemporal functional architecture of executive control, in NeuroImage, 215, 116811-116811.
Brain structural evidence for a frontal pole specialization in glossolalia
Walter Yoshija, Dieguez Sebastian, Mouthon Michael, Spierer Lucas (2020), Brain structural evidence for a frontal pole specialization in glossolalia, in IBRO Reports, 23.
Stimulus Reward Value Interacts with Training-induced Plasticity in Inhibitory Control
De Pretto Michael, Hartmann Lea, Garcia-Burgos David, Sallard Etienne, Spierer Lucas (2019), Stimulus Reward Value Interacts with Training-induced Plasticity in Inhibitory Control, in Neuroscience, 421, 82-94.
Practice-induced functional plasticity in inhibitory control interacts with aging
Hartmann Lea, Wachtl Laura, de Lucia Marzia, Spierer Lucas (2019), Practice-induced functional plasticity in inhibitory control interacts with aging, in Brain and Cognition, 132, 22-32.
Modulation of inhibitory control by prefrontal anodal tDCS: A crossover double-blind sham-controlled fMRI study
Sallard Etienne, Mouthon Michael, De Pretto Michael, Spierer Lucas (2018), Modulation of inhibitory control by prefrontal anodal tDCS: A crossover double-blind sham-controlled fMRI study, in PLOS ONE, 13(3), e0194936-e0194936.

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
Cognition Day UNIFR Talk given at a conference Inhibitory control training, from fundamental to applied science 15.10.2020 Fribourg, Switzerland Spierer Lucas; Najberg Hugo;


Knowledge transfer events

Active participation

Title Type of contribution Date Place Persons involved
Gerontopole Performances, exhibitions (e.g. for education institutions) 01.10.2019 Fribourg, Switzerland Spierer Lucas;


Communication with the public

Communication Title Media Place Year
Talks/events/exhibitions Numerik Games Festival Western Switzerland 2019

Associated projects

Number Title Start Funding scheme
156854 Structural and functional brain plasticity in inhibitory control: towards expertise 01.01.2015 Project funding
143348 Training-induced behavioral and brain plasticity in inhibitory control 01.01.2013 Project funding

Abstract

1. Summary: ‘State-dependency of inhibitory control plasticity’ 1.1 Background Inhibitory control (IC), a key aspect of executive functions, refers to the ability to suppress cognitive or motor processes and is mainly supported by a right fronto-basal brain network. IC exhibits a high degree of experience-dependent plasticity; IC training typically results in an increase in the speed of the inhibition process associated with a reduction of right ventrolateral prefrontal activity and a reinforcement of fronto-striatal anatomic connectivity. However, while the neurocognitive mechanisms of experience-dependent IC plasticity in young healthy populations begin to be elucidated, how the pre-training anatomo-functional context modulates the expression of IC plasticity remains unknown. We plan to examine the effects of aging, non-invasive brain stimulation and brain lesions on training-induced plasticity in inhibitory control. 1.2 Working hypotheses Project A. Age-related inhibitory control deficits are associated with an increase in right inferior frontal activity and an additional recruitment of contralateral homotopic areas, a pattern interpreted as a compensatory functional response to age-related neural deteriorations. Interestingly, this functional reorganization pattern is qualitatively similar to the plastic modifications induced by training in young adults, but in the opposite direction. >IC training in elderly should ‘reverse’ the effects of aging on inhibitory control functional architecture. Project B. The reduction of ventrolateral prefrontal neural activity associated with IC training has been advanced as being regulated by the central nervous system inhibitory/excitatory balance, a mechanism that can be locally and bidirectionally modulated by transcranial direct current stimulation (tDCS). >Cathodal inhibitory tDCS should potentiate the training-induced (supposedly GABA-mediated) sharpening of inhibition-related ventrolateral prefrontal activity and in turn enhance the effects of inhibitory control training. Project C. The pathophysiological brain response to lesions interacts with the cognitive and functional symptomatology, as well as with training-induced plasticity, in a time-dependent manner.>Lesions close to (but sparing) the fronto-basal IC network, or in contralateral homotopic areas, should impair IC-related functional activity and the effects of IC training during the acute and subacute phases, whereas lesions outside the IC network should influence these dependent variables in the acute phase only. 1.3 Experimental designs and methods Projects A and B are based on confirmatory double-blind randomized actively-controlled intervention trials combined with electrical neuroimaging. The effects of multi-sessions training regimens and their transfer to untrained tasks will be assessed with Intervention Group x Pre/Post Training Session interaction terms. The control and experimental conditions are equated for task demands and participants’ expectations, ensuring a stringent level of control for the effects of the tested interventions. Project C is based on a longitudinal investigation of the interaction between lesions spatial features, post-lesion delays and training-induced functional IC plasticity with voxel-based lesion-symptom mapping analyses. 1.4 Expected value of the proposed project The planned projects will answer key questions on the neurocognitive mechanisms of inhibitory control and of its plasticity based on unique combinations of lesion, electrical neuroimaging and brain stimulation approaches. The studies are designed to have an immediate clinical applicability, including the development of targeted diagnosis and rehabilitation strategies for elderly and clinical populations with inhibitory control deficits.
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