Project

Back to overview

Interventional and susceptibility artifact-free MR Imaging

Applicant Salameh Najat
Number 170575
Funding scheme SNSF Professorships
Research institution Departement Biomedical Engineering Universität Basel
Institution of higher education University of Basel - BS
Main discipline Other disciplines of Physics
Start/End 01.05.2017 - 30.04.2021
Approved amount 1'608'285.86
Show all

Keywords (10)

Low magnetic field MRI; Implanted devices; Iron overload; MR sequence development; MR hardware development; Interventional MRI; MR Elastography; MR-guided therapies; MRI; Magnetic susceptibility

Lay Summary (French)

Lead
L'Imagerie par Résonance Magnétique (IRM) a révolutionné le diagnostic en médecine, permettant d'obtenir de façon non invasive des images du corps humain très bien résolues avec un contraste à ce jour inégalé. Le fonctionnement des appareils IRM cliniques repose sur l’emploi de champs magnétiques intenses (=1.5T) qui limitent leur flexibilité et imposent des précautions d'usage très strictes, dont l'incidence varie de la présence d'inhomogénéité sur les images jusqu'à un risque direct pour l'intégrité physique des personnes. Ainsi, l'IRM est p.ex. contre-indiquée en présence d'implants ou de surcharge en fer. La tomodensitométrie -ionisante- ou la biopsie -invasive- peuvent alors aider mais ne suffisent pas pour un diagnostic précis ou lors d'examens répétés pour un suivi thérapeutique. Quant à la chirurgie guidée par imagerie, le suivi par IRM suscite un intérêt croissant, mais est freiné face aux maints défis imposés par la présence d'aimants puissants et l'accès limité au patient.
Lay summary

CONTENU ET OBJECTIFS

Nous proposons de travailler à plus bas champ magnétique afin d'immuniser les techniques d'IRM aux changements de susceptibilité magnétique. Dans ce nouveau référentiel, les champs d'application de l'IRM s'ouvrent à plus de flexibilité ne nécessitant plus d'environnement parfaitement non-magnétique. Ce type d'imageur n'étant pas disponible sur le marché, nous allons fabriquer notre propre plateforme en nous basant sur une technologie d'aimant résistif, plus flexible, moins cher et moins lourd que les aimants supraconducteurs actuellement utilisés. Sur cette plateforme unique en Suisse, nous ferons varier le champ magnétique entre 0.03 et 0.10 T et nous y développerons tous les outils nécessaires à l'exploration de nouveaux contrastes critiques pour le diagnostic des maladies chroniques du foie avec surcharge en fer, ainsi que pour le suivi chirurgical intra-opératif (partenariat avec le projet MIRACLE).

CONTEXTE SCIENTIFIQUE ET SOCIETAL

Les développements sur les scanners à champs magnétiques modérés (0.1 - 0.3 T) ont été complètement abandonnés il y a une vingtaine d'années au profit d'une course au haut champ magnétique. Ces champs intenses offrent rapidité et performance mais sont très peu flexibles, sont contre-indiqués chez de nombreux patients, et sont extrêmement chers dans un contexte socioéconomique tendu. Moderniser l'IRM à champs faibles avec des technologies de pointe permet à la fois plus de flexibilité (suivi intra-opératif), l'exploration de nouveaux contrastes, et une réduction des coûts liés à la santé. Ce projet a deux impacts majeurs : scientifique car il permet d'étudier tout un volet de la physique de l'IRM dans un régime encore peu exploré, et économique car il ouvre la voie à des technologies modernes, robustes, et à coûts modérés.

Direct link to Lay Summary Last update: 17.03.2017

Responsible applicant and co-applicants

Employees

Publications

Publication
Quantitative MRI to Characterize the Nucleus Pulposus Morphological and Biomechanical Variation According to Sagittal Bending Load and Radial Fissure, an ex vivo Ovine Specimen Proof-of-Concept Study
Deneuville Jean-Philippe, Yushchenko Maksym, Vendeuvre Tanguy, Germaneau Arnaud, Billot Maxime, Roulaud Manuel, Sarracanie Mathieu, Salameh Najat, Rigoard Philippe (2021), Quantitative MRI to Characterize the Nucleus Pulposus Morphological and Biomechanical Variation According to Sagittal Bending Load and Radial Fissure, an ex vivo Ovine Specimen Proof-of-Concept Study, in Frontiers in Bioengineering and Biotechnology, 9, 676003.
Elastography Validity Criteria Definition Using Numerical Simulations and MR Acquisitions on a Low-Cost Structured Phantom
Yushchenko Maksym, Sarracanie Mathieu, Amann Michael, Sinkus Ralph, Wuerfel Jens, Salameh Najat (2021), Elastography Validity Criteria Definition Using Numerical Simulations and MR Acquisitions on a Low-Cost Structured Phantom, in Frontiers in Physics, 9, 620331.
Towards Tracking of Deep Brain Stimulation Electrodes Using an Integrated Magnetometer
Quirin Thomas, Féry Corentin, Vogel Dorian, Vergne Céline, Sarracanie Mathieu, Salameh Najat, Madec Morgan, Hemm Simone, Hébrard Luc, Pascal Joris (2021), Towards Tracking of Deep Brain Stimulation Electrodes Using an Integrated Magnetometer, in Sensors, 21(8), 2670-2670.
Low-Field MRI: How Low Can We Go? A Fresh View on an Old Debate
Sarracanie Mathieu, Salameh Najat (2020), Low-Field MRI: How Low Can We Go? A Fresh View on an Old Debate, in Frontiers in Physics, 8, 172.
Re-envisioning low-field MRI
SalamehNajat, SarracanieMathieu (2020), Re-envisioning low-field MRI, 76, 1.
Remote palpation of the human brain with magnetic resonance imaging: protocol optimization for the study of glioblastoma
Yushchenko M., Sarracanie M., Amann M., Sinkus R., Wuerfel J., Salameh N. (2019), Remote palpation of the human brain with magnetic resonance imaging: protocol optimization for the study of glioblastoma, in Computer Methods in Biomechanics and Biomedical Engineering, 22(sup1), S348-S349.
An Overhauser-enhanced-MRI platform for dynamic free radical imaging in vivo
Waddington David E. J., Sarracanie Mathieu, Salameh Najat, Herisson Fanny, Ayata Cenk, Rosen Matthew S. (2018), An Overhauser-enhanced-MRI platform for dynamic free radical imaging in vivo, in NMR in Biomedicine, 31(5), e3896-e3896.
Nanodiamond-enhanced MRI via in situ hyperpolarization
Waddington David E. J., Sarracanie Mathieu, Zhang Huiliang, Salameh Najat, Glenn David R., Rej Ewa, Gaebel Torsten, Boele Thomas, Walsworth Ronald L., Reilly David J., Rosen Matthew S. (2017), Nanodiamond-enhanced MRI via in situ hyperpolarization, in Nature Communications, 8(1), 15118-15118.

Collaboration

Group / person Country
Types of collaboration
Haute Ecole de Santé - HES SO Geneva Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Photomécanique & analyse Expérimentale en Mécanique des solides / Institut P' - Uni. Poitiers France (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Laboratoire de biorhéologie et d'ultrasonographie médicale / CRCHUM Uni Montréal Canada (North America)
- in-depth/constructive exchanges on approaches, methods or results
Dept. of Biomedical Engineering - St. Thomas’ Hospital Great Britain and Northern Ireland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Carp lab / A.A. Martinos center for biomedical imaging - Harvard Medical School United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Quantitative Biomedical Imaging group / Uni Basel Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Comment Group - CIBM/EPFL Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
MIAC AG Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Department of Radiology and Medical Informatics - University Hospital Geneva Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
BioMaps / Université Paris-Saclay France (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
Institute for Medical Engineering and Medical Informatics Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
45th congress of the Biomechanics Society Talk given at a conference The biomechanical nature of nucleus pulposus in a fissured disc revealed by quantitative MRI performed under dynamic conditions 26.10.2020 Metz, France Salameh Najat; Sarracanie Mathieu; Yushchenko Maksym;
ESMRMB annual meeting Poster Deep learning for reconstruction of undersampled low-field MRI 30.09.2020 online, Spain Salameh Najat; Yushchenko Maksym; Fiorito Marco; Sarracanie Mathieu;
ESMRM annual meeting Poster In-vivo imaging using an open biplanar volume coil at 0.1 T 30.09.2020 online, Spain Sarracanie Mathieu; Yushchenko Maksym; Salameh Najat;
ESMRMB annual meeting Poster Fast, interleaved Look-Locker based T1* mapping for low-field MR thermometry 30.09.2020 online, Spain Fiorito Marco; Salameh Najat; Yushchenko Maksym; Sarracanie Mathieu;
ESMRMB annual meeting Poster The biomechanical nature of nucleus pulposus in a fissured disc revealed by quantitative MRI performed under dynamic conditions 30.09.2020 online, Spain Sarracanie Mathieu; Salameh Najat; Yushchenko Maksym;
ESMRMB annual meeting Poster High-input impedance preamplifiers for multi-channel strategies at low frequency 30.09.2020 online, Spain Yushchenko Maksym; Salameh Najat; Sarracanie Mathieu;
ESMRMB annual meeting Poster T1- and T2-prepared SSFP sequences for fast relaxometry at low field 30.09.2020 online, Spain Salameh Najat; Yushchenko Maksym; Fiorito Marco; Sarracanie Mathieu;
ISMRM annual meeting Poster Development of a biplanar volume coil for an open 0.1 T MRI system 08.08.2020 online, Australia Sarracanie Mathieu; Yushchenko Maksym; Salameh Najat;
ISMRM annual meeting Poster A low-cost versatile phantom for elastography 08.08.2020 online, Australia Sarracanie Mathieu; Salameh Najat; Yushchenko Maksym;
ISMRM annual meeting Talk given at a conference Low field MR thermometry with a fast, interleaved Look-Locker based T1 mapping approach 08.08.2020 online, Australia Fiorito Marco; Sarracanie Mathieu; Salameh Najat; Yushchenko Maksym;
Siemens MAGNETOM World Summit Talk given at a conference Accessible MRI: economic & technological challenges 09.07.2020 online, Canada Sarracanie Mathieu; Salameh Najat;
ISMRM Virtual meeting - Engineering study group Talk given at a conference Low-field initiatives – an overview 04.06.2020 online, United States of America Salameh Najat; Sarracanie Mathieu;
ESMRMB annual meeting Talk given at a conference Optimizing robustness and accuracy of MR elastography for the diagnosis and follow-up of glioblastoma patients 03.10.2019 Rotterdam, Netherlands Salameh Najat; Yushchenko Maksym; Sarracanie Mathieu;
ESMRMB annual meeting Talk given at a conference Low magnetic field MR imaging 03.10.2019 Rotterdam, Netherlands Sarracanie Mathieu; Salameh Najat;
ISMRM Workshop on MR Value Talk given at a conference Low magnetic field MR imaging 11.03.2019 Edimbourg, Great Britain and Northern Ireland Salameh Najat; Sarracanie Mathieu;
Seminar series - MR perspectives Individual talk Remote palpation with Mr 29.11.2018 Allschwil, Switzerland Salameh Najat;
Forum Biomécanique Talk given at a conference Caractérisation des tissus par élastographie IRM 26.06.2018 Poitiers, France Salameh Najat; Sarracanie Mathieu;
DBE Research Day Talk given at a conference Interventional and susceptibility artifact-free MR Imaging 23.08.2017 Basel University, Switzerland Salameh Najat; Sarracanie Mathieu;


Self-organised

Title Date Place
Training school in NMR relaxometry and MR Imaging 13.02.2019 Allschwil, Switzerland

Knowledge transfer events

Active participation

Title Type of contribution Date Place Persons involved
Low magnetic field MRI - Swiss Innovation Park / Basel Area Performances, exhibitions (e.g. for education institutions) 04.06.2019 Allschwil, Switzerland Yushchenko Maksym;
Low magnetic field MRI - Swiss Innovation Park / Basel Area Performances, exhibitions (e.g. for education institutions) 21.03.2019 Allschwil, Switzerland Sarracanie Mathieu; Salameh Najat;
Entrepreneur Club - Basel University Innovation Office Workshop 27.11.2018 Allschwil, Switzerland Salameh Najat; Sarracanie Mathieu;
Low magnetic field MRI - Swiss Innovation Park / Basel Area Performances, exhibitions (e.g. for education institutions) 01.10.2018 Allschwil, Switzerland Salameh Najat; Sarracanie Mathieu;
MR Physics Talk 03.05.2017 MIAC AG, Switzerland Sarracanie Mathieu; Salameh Najat;


Communication with the public

Communication Title Media Place Year
Media relations: print media, online media What does the future hold now for low-field MRI systems? Aunt Minnie Europe International 2021
Media relations: print media, online media Des appareils d’imagerie médicale plus petits sont possibles Horizons Italian-speaking Switzerland Western Switzerland German-speaking Switzerland 2019
Media relations: print media, online media Shaping the future of MRI Innovation Park Newsletter Western Switzerland German-speaking Switzerland Italian-speaking Switzerland 2018
Other activities Adaptable MRI Technology German-speaking Switzerland 2017
Media relations: radio, television TV news - Swiss Innovation Park RTS Western Switzerland 2017

Associated projects

Number Title Start Funding scheme
198905 Interventional and susceptibility artifact-free MR Imaging 01.05.2021 SNSF Professorships

Abstract

Medical imaging techniques have radically transformed the landscape of modern diagnosis and therapy by giving full access to the internal structure and function of the body. Magnetic Resonance Imaging (MRI), in particular, enables high-resolution imaging of the human body with unmatched soft-tissue contrast in a completely non-invasive and non-ionizing manner. Unfortunately, clinical MRI scanners operate at very high magnetic fields (1.5 T, 3 T) that increase their intrinsic sensitivity but also sensitize them to magnetic material in general, thus precluding their use for a wide range of applications. In patients with implanted devices or iron overload, MRI is typically contraindicated and ionizing Computed Tomography (CT) or invasive biopsies can help, but do not suffice for accurate diagnosis or repetitive examinations as treatment follow-up. For interventional medicine, the interest in MRI monitoring is increasing but has difficulty to develop due to the many challenges posed by the presence of powerful magnets and radio frequency equipment inside an operating room. By design, MRI high-field magnets are not flexible and provide very little space for surgeons, and custom-designed, non-magnetic and non-electrically conductive equipment is mandatory to protect patients and staff from undesirable accidents. Furthermore, the compliance with non-magnetic environments is needed to ensure that scans are free from undesired image artifacts and severe signal losses. Typically found at interfaces (e.g. at air-tissue interfaces, in iron-overloaded tissues, or around implanted devices), magnetic susceptibility differences cause nuclear spins to lose coherence in magnetic field gradients and can result in image distortions, ghosting artifacts and dramatic signal losses.Operating at low magnetic fields, however, allows being much less sensitive and even immune to magnetic susceptibility changes, offers great flexibility for the design of open geometry scanners, and thus provides the ground for new applications not requiring a completely non-magnetic environment. In recent work, I have investigated new approaches that mitigate the substantial loss in sensitivity inherent to the low field regime, and showed the feasibility of high performance imaging. Low magnetic fields would permit MRI in the presence of iron or implanted devices, which is critical in the fields of iron-overloaded organs (like hemochromatosis) and image-guided therapies.
-