Project

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TT-PET: Thin Time-of-Flight PET with depth of interaction measurement capability based on very-low noise Silicon-Germanium BJT electronics and semiconductor detector

English title TT-PET: Thin Time-of-Flight PET with depth of interaction measurement capability based on very-low noise Silicon-Germanium BJT electronics and semiconductor detector
Applicant Iacobucci Giuseppe
Number 160808
Funding scheme Sinergia
Research institution Département de physique nucléaire et corpusculaire Université de Genève
Institution of higher education University of Geneva - GE
Main discipline Technical Physics
Start/End 01.03.2016 - 31.10.2019
Approved amount 1'872'738.00
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Keywords (3)

silicon-germanium chips; PET; silicon

Lay Summary (French)

Lead
TT-PET: Thin Time-of-Flight PET with depth of interaction measurement capability based on very-low noise Silicon-Germanium BJT electronics and semiconductor detector
Lay summary

La tomographie par émission de positons (PET) est l'un des piliers de la médecine nucléaire moderne. Il est à la fois  un outil clinique et de recherche avec un spectre important et croissant d'applications. Les systèmes d'imagerie PET ont été initialement développées à partir de technologies typiques des expériences de physique des particules. Aujourd'hui, l'expérience acquise avec la construction des détecteurs du grandes collisionneur de hadrons LHC du CERN est prêt pour être traduit en de nouvelles idées pour des technologies de pointe pour PET. 

Dans ce projet, des détecteurs à semi-conducteurs minces en combinaison avec une électronique de lecture très rapide et de très faible bruit de fond, développés pour l’experience ATLAS du LHC, sont proposés pour la réalisation d’un système PET de très haute precision. 

 

Direct link to Lay Summary Last update: 24.11.2015

Responsible applicant and co-applicants

Employees

Publications

Publication
A monolithic ASIC demonstrator for the Thin Time-of-Flight PET scanner
Valerio P., Cardarelli R., Iacobucci G., Paolozzi L., Ripiccini E., Hayakawa D., Bruno S., Caltabiano A., Kaynak M., Rücker H., Nessi M. (2019), A monolithic ASIC demonstrator for the Thin Time-of-Flight PET scanner, in Journal of Instrumentation, 14(07), P07013-P07013.
Characterization of the demonstrator of the fast silicon monolithic ASIC for the TT-PET project
Paolozzi L., Bandi Y., Cardarelli R., Débieux S., Favre Y., Ferrère D., Forshaw D., Hayakawa D., Iacobucci G., Kaynak M., Miucci A., Nessi M., Ripiccini E., Rücker H., Valerio P., Weber M. (2019), Characterization of the demonstrator of the fast silicon monolithic ASIC for the TT-PET project, in Journal of Instrumentation, 14(02), P02009-P02009.
Expected performance of the TT-PET scanner
RipicciniE. et al. (2018), Expected performance of the TT-PET scanner, in arxiv, 1811.12381.
Module concept and thermo-mechanical studies of the silicon-based TT-PET small-animal scanner
(2018), Module concept and thermo-mechanical studies of the silicon-based TT-PET small-animal scanner, in arxiv, 1812.00788.
The TT-PET Data Acquisition and Trigger System
Bandi Yves et al. (2018), The TT-PET Data Acquisition and Trigger System, in arxiv, 1812.03958.
100 ps time resolution with thin silicon pixel detectors and a SiGe HBT amplifier
M. Benoit R. Cardarelli S. Débieux Y. Favre G. Iacobucci M. Nessi L. Paolozzi and K. Shu (2016), 100 ps time resolution with thin silicon pixel detectors and a SiGe HBT amplifier, in JINST, 11, 1.
Test beam measurement of the first prototype of the fast silicon pixel monolithic detector for the TT-PET project
Paolozzi Lorenzo et al., Test beam measurement of the first prototype of the fast silicon pixel monolithic detector for the TT-PET project, in JINST.

Collaboration

Group / person Country
Types of collaboration
Università di Roma Tor Vergata Italy (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
Stanford University, MIPS United States of America (North America)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
- Exchange of personnel

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
15th Vienna Conference on Instrumentation (VCI2019) Talk given at a conference Development of the Thin TOF-PET scanner based on fast monolithic silicon pixel sensors 01.02.2019 Vienna, Austria Hayakawa Daiki;
9th International Workshop on Semiconductor Pixel Detectors for Particles and Imaging (PIXEL2018) Talk given at a conference Development of fast, monolithic silicon pixel sensors in a SiGe Bi-CMOS process 10.12.2018 Taipei, China Paolozzi Lorenzo;
Workshop for Development and Applications of Fast timing Semiconductor Devices Talk given at a conference Development of the Thin TOF-PET scanner based on fast monolithic silicon pixel sensors 01.12.2018 Tsukuba, Japan Hayakawa Daiki;
2nd Sino-Swiss Space Science Workshop Talk given at a conference Timing with silicon detectors: a new perspective 13.09.2018 Beijing, China Iacobucci Giuseppe;
Annual Meeting of the Swiss Physical Society Talk given at a conference Development of Fast Timing Silicon Monolithic Pixel Sensors and Image Reconstruction for Positron Emission Tomography 01.08.2018 EPFL, Lausanne, Switzerland Hayakawa Daiki;
NUVPET Workshop Talk given at a conference The TT-PET Project: a 30ps Time-Of-Flight PET scanner with silicon pixels 18.04.2018 EPFL, Neuchâtel, Switzerland Iacobucci Giuseppe;
XIV Workshop on Resistive Plate Chambers and Related Detectors (RPC 2018) Talk given at a conference Development of semiconductor solid-state detectors with sub-100ps time resolution 01.02.2018 Puerto Vallarta, Mexico Paolozzi Lorenzo;
Hiroshima 2017 Symposium Poster Fast timing Silicon monolithic pixel sensor for TOF-PET 10.12.2017 Okinawa, Japan Hayakawa Daiki;
TWEPP2017 Talk given at a conference A High-precision Timing ASIC for TOF-PET applications 11.09.2017 Santa Cruz, United States of America Valerio Pierpaolo;
PSD17 Talk given at a conference The TT-PET project: a thin TOF-PET scanner based on fast novel silicon detectors 03.09.2017 Dresden, Germany Bandi Yves;
Joint Annual Meeting of the Swiss and Austrian Physical Society Poster Development of Fast Timing Silicon Pixel Sensors for Positron Emission Tomography 01.08.2017 Geneva, Germany Hayakawa Daiki;
PSM2017, Lisbon Talk given at a conference The TT-PET project: a thin TOF-PET scanner based on fast monolithic silicon detectors 29.05.2017 Lisbon, Portugal Ripiccini Emanuele;
TIPP17, Beijing Talk given at a conference A fast monolithic pixel detector in a SiGe Bi-CMOS process 22.05.2017 Beijing, China Paolozzi Lorenzo;
Workshop on Advanced Silicon Radiation Detectors Individual talk Silicon monolithic pixel detectors in a SiGe Bi-CMOS process for sub-100ps time resolution 20.02.2017 Trento, Italy Paolozzi Lorenzo;
CHIPP Winter School 2017 Poster Development of thin time-of-flight PET scanner 13.02.2017 Soerenberg, Switzerland Bandi Yves;
Mu3e external meeting Individual talk Fast SiGe Pixel Detectors 13.02.2017 Wengen, Switzerland Iacobucci Giuseppe;
2016 SPS meeting Talk given at a conference Construction of a time of flight positron emission tomography system 22.08.2016 Lugano, Switzerland Bandi Yves;
10th International Meeting on Front-End Electronics (FEE 2016) Talk given at a conference 100ps time resolution for silicon pixel detectors 30.06.2016 Krakow, Poland Paolozzi Lorenzo;


Awards

Title Year
Lorenzo Paolozzi obtained the grant INNOGAP from the technology transfer of the University of Geneva to produce the demonstrator of a monolithic sensor for pulsed infrared light based on the developments done for the TT-PET project. The project name is "Monolithic detector in a commercial SiGe BiCMOS technology for time measurements with pulsed IR light sources". The funding for this development is 25500 CHF. The project will last 12 month, starting from June 2018. 2017

Patents

Title Date Number Inventor Owner
Device and method for measuring the relative time of arrival of signals 02.07.2018 EP 18181123.3

Associated projects

Number Title Start Funding scheme
198569 The 100µPET project: Pioneering ultra-high resolution molecular imaging 01.06.2021 Sinergia
164029 A probe system for novel silicon detectors for the High-Luminosity LHC, astroparticle experiments in space and medical applications 01.06.2016 R'EQUIP

Abstract

Positron Emission Tomography (PET) is one of the pillars of modern nuclear medicine. It is today both a clinical and a research tool with a large and growing spectrum of clinical applications for diagnosis and treatment monitoring of a variety of diseases. A key component of PET imaging systems are the detector modules, an area of research and development that has often seen the migration of technologies originally developed for particle physics experiments. As of today, the experience gained with the construction of the Large Hadron Collider (LHC) detectors is mature to be translated into new ideas for PET technologies, provided adequate effort and resources are devoted to the task. In particular, the availability of a new generation of thin solid-state detectors based on silicon in combination with very-low noise and very fast readout electronics is now opening a new window of before unexpected opportunities. What is proposed in this SINERGIA is a compact and thin time-of-flight PET detector device with depth of interaction measurement capability, which employs:-thin foils of Bismuth as photon conversion material;-thin foils of silicon-dioxide to absorb background electrons from low-energy scattered photons;-layered silicon sensors as active material, read out on both ends by pick-up strips with 1 mm pitch;-a readout consisting of a new generation of very-low noise and very fast electronics based on Si-Ge Bipolar-Junction Transistor (BJT) components.The goal is to reach a time-of-flight measurement precision of 30 picoseconds or better, to maximize the spatial resolution along the line of flight of the two photons emitted by positron annihilation in matter, and a 3D detection granularity down to 1.0×1.2(RMS)×0.2 mm3, consequently improving the quality, the contrast and the uniformity of the image. This major breakthrough in time resolution will allow drastic reduction of backgrounds and therefore reduction of the dose of radioisotopes delivered to the patient. The high precision 3D reconstruction of the photon interaction point on the detector will also allow excellent photon tracking capability disregarding the emission angle.Another important feature is that such compact devices, assembled in rings, will allow more efficient combination of MRI and PET in clinically acclaimed hybrid scanners that are regarded as the next quantum leap in molecular imaging in medicine.This proposal is based on first prototype measurements and on specific simulations to show the full feasibility of the project. The composition of the proposed SINERGIA collaboration will allow detector physicists and specialized microelectronics engineers of the Geneva and Bern LHC communities to construct a working device and qualify it in existing test facilities. The Geneva HUG/ITMI and the Stanford/MIPS groups, that include bio-physicists with world-leading expertise in imaging techniques, will allow rapid and full control of the software for the reconstruction of structures, and the development of ad-hoc new filtering algorithms and data correction methods. This proposal deals with the R&D on the detectors, on the Si-Ge BJT ASIC and on the reconstruction software; its primary deliverable is the measurement of a phantom with a full ring of the detector (10cm in diameter), eventually immersed in an MRI scanner. To obtain an excellent time-resolution with long strips, keeping the number of readout channels small, it is proposed to match the impedance of the electronics to the read-out strips of the silicon detectors. It should be noted that this method, already used for large area gaseous detectors but never for silicon, has many potential applications in medical, space and high-energy physics and represents an important R&D project by itself.If successful, continuation of the project for further three years is foreseen, which will envisage measurements with small animals and maybe human bodies with a larger detector.
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