Immune deficiency; Antiretroviral therapy; HIV; drug resistance; side effects; toxicity; virus host interactions; hiv epidemic
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Trickey Adam, May Margaret T, Schommers Philipp, Tate Jan, Ingle Suzanne M, Guest Jodie L, Gill M John, Zangerle Robert, Saag Mike, Reiss Peter, Monforte Antonella d'Arminio, Johnson Margaret, Lima Viviane D, Sterling Tim R, Cavassini Matthias, Wittkop Linda, Costagliola Dominique, Sterne Jonathan A C, Sterne Jonathan A C (2017), CD4:CD8 Ratio and CD8 Count as Prognostic Markers for Mortality in Human Immunodeficiency Virus-Infected Patients on Antiretroviral Therapy: The Antiretroviral Therapy Cohort Collaboration (ART-CC)., in
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Gebreselassie HM, Kraus D, Fux CA, Haubitz S, Scherrer A, Hatz C, Veit O, Stoeckle M, Fehr J, de Lucia S, Cavassini M, Bernasconi E, Schmid P, Furrer H, Staehelin C (2017), Ethnicity predicts viral rebound after travel to the tropics in HIV-infected travelers to the tropics in the Swiss HIV Cohort Study, in
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Alvarez-Del Arco Debora, Fakoya Ibidun, Thomadakis Christos, Pantazis Nikos, Touloumi Giota, Gennotte Anne-Francoise, Zuure Freke, Barros Henrique, Staehelin Cornelia, Göpel Siri, Boesecke Christoph, Prestileo Tullio, Volny-Anne Alain, Burns Fiona, Del Amo Julia, aMASE (Advancing Migrant Access to Health Services in Europe) study team (2017), High levels of post-migration HIV acquisition within nine European countries., in
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Negoescu Diana M., Zhang Zhenhuan, Bucher Heiner C., Bendavid Eran (2017), Differentiated Human Immunodeficiency Virus RNA Monitoring in Resource-Limited Settings: An Economic Analysis, in
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Blanquart François, Wymant Chris, Cornelissen Marion, Gall Astrid, Bakker Margreet, Bezemer Daniela, Hall Matthew, Hillebregt Mariska, Ong Swee Hoe, Albert Jan, Bannert Norbert, Fellay Jacques, Fransen Katrien, Gourlay Annabelle J., Grabowski M. Kate, Gunsenheimer-Bartmeyer Barbara, Günthard Huldrych F., Kivelä Pia, Kouyos Roger, Laeyendecker Oliver, Liitsola Kirsi, Meyer Laurence, Porter Kholoud, Ristola Matti, et al. (2017), Viral genetic variation accounts for a third of variability in HIV-1 set-point viral load in Europe, in
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Combes Jean-Damien, Clifford Gary M., Egger Matthias, Cavassini Matthias, Hirsch Hans H., Hauser Christoph, Calmy Alexandra, Schmid Patrick, Bernasconi Enos, Günthard Huldrych F., Franceschi Silvia, Waterboer Tim, Scherrer Alexandra U. (2017), Human papillomavirus antibody response following HAART initiation among MSM, in
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Nakagawa Fumiyo, van Sighem Ard, Thiebaut Rodolphe, Smith Colette, Ratmann Oliver, Cambiano Valentina, Albert Jan, Amato-Gauci Andrew, Bezemer Daniela, Campbell Colin, Commenges Daniel, Donoghoe Martin, Ford Deborah, Kouyos Roger, Lodwick Rebecca, Lundgren Jens, Pantazis Nikos, Pharris Anastasia, Quinten Chantal, Thorne Claire, Touloumi Giota, Delpech Valerie, Phillips Andrew, SSOPHIE project working group in EuroCoord (2016), A Method to Estimate the Size and Characteristics of HIV-positive Populations Using an Individual-based Stochastic Simulation Model., in
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The Swiss HIV Cohort Study (SHCS), established in 1988, is an ongoing, longitudinal, clinic-based cohort of HIV-1 infected adults. Until to date, cumulatively, 17'795 persons have been enrolled. The strength of the cohort is the comprehensive collection of clinical, laboratory and socio-demographic data as well as biological samples from enrolled individuals every 3 - 6 months accompanied by a strict quality control program. The size and duration of the cohort allowed for the formation of a world-wide exceptional biobank which currently contains > 1.3 mio specimens from HIV infected individuals and thereby provides a unique research platform for clinical, translational, epidemiological, social and basic research worldwide. Due to its continuing success in recruiting patients, the SHCS is representative of the Swiss HIV-1 infected population. Likewise, due to its longevity, comprehensive and high quality data collection, the SHCS will continue to provide invaluable data for public health as best evidenced by the major impact on the high quality of HIV care the SHCS has had in Switzerland. An important reason for this success remains that all key players in Swiss HIV medicine are participating in the SHCS which guarantees that research results are rapidly transformed into clinical care. With its drug resistance database containing > 19000 pol genotypes and its host genetic database of > 2500 whole human genomes, the SHCS is in a position to actively contribute to large international collaborations to resolve research questions that cannot be resolved by single cohorts. Key to success of the SHCS are also two further important factors, the clear dedication to a multidisciplinary approach which promotes crossing of conventional research areas and the system of nested research projects that allows to rapidly respond to the needs of the continuously changing HIV epidemic.