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Approaches for Non-spherical and Surface Activated Liposomes

English title Approaches for Non-spherical and Surface Activated Liposomes
Applicant Zumbühl Andreas
Number 138926
Funding scheme SNSF Professorships
Research institution Département de Chimie Université de Fribourg
Institution of higher education University of Fribourg - FR
Main discipline Organic Chemistry
Start/End 01.08.2012 - 31.07.2016
Approved amount 1'638'566.00
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All Disciplines (4)

Discipline
Organic Chemistry
Other disciplines of Physics
Material Sciences
Biomedical Engineering

Keywords (10)

Phospholipid Synthesis; Membrane Biophysics; Phospholipid Monolayers; Temporomandibular joint disorder; Large unilamellar vesicles; Solid phase synthesis; Biomedical Engineering; Giant unilamellar vesicles; Bioorganic Chemistry; Vesicle Origami

Lay Summary (German)

Lead
Lay summary

Das vorliegende Projekt befasst sich mit mikroskopisch kleinen, Seifenblasen-ähnlichen Nanocontainern. Diese können mit Medikamenten gefüllt werden dienen schon heute als innovative Formulierungen, welche z.B. Nebeneffekte minimieren.

Wir beschäftigen und mit der Synthese von neuen Molekülen, welche solche Nanocontainer bilden. Durch die Wahl geeigneter Moleküle können wir die Form der Nanocontainer verändern sodass diese nicht mehr rund sind und auf spezielle Scherkräfte im menschlichen Körper reagieren können.

Durch das Zusammenspiel von Grundlagenforschung und angewandter Forschung erhoffen wir uns einen Innovoationsschub in der Liposomenforschung.
Direct link to Lay Summary Last update: 21.02.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
Characterization of mechano-sensitive nano-containers for targeted vasodilation
Buscema Marzia, Deyhle Hans, Pfohl Thomas, Hieber Simone E., Zumbuehl Andreas, Müller Bert (2016), Characterization of mechano-sensitive nano-containers for targeted vasodilation, in SPIE Smart Structures and Materials + Nondestructive Evaluation and Health Monitoring, Las Vegas, Nevada, United StatesSPIE, Las Vegas.
Surprising lack of liposome-induced complement activation by artificial 1,3-diamidophospholipids in vitro
Bugna Simon, Buscema Marzia, Matviykiv Sofiya, Urbanics Rudolf, Weinberger Andreas, Meszaros Tamas, Szebeni Janos, Zumbuehl Andreas, Saxer Till, Müller Bert (2016), Surprising lack of liposome-induced complement activation by artificial 1,3-diamidophospholipids in vitro, in Nanomedicine: Nanotechnology, Biology and Medicine, 12(3), 845-849.
Surprising lack of liposome-induced complement activation by artificial 1,3-diamidophospholipids in vitro.
Bugna Simon, Buscema Marzia, Matviykiv Sofiya, Urbanics Rudolf, Weinberger Andreas, Meszaros Tamas, Szebeni Janos, Zumbuehl Andreas, Saxer Till, Müller Bert (2016), Surprising lack of liposome-induced complement activation by artificial 1,3-diamidophospholipids in vitro., in Nanomedicine : nanotechnology, biology, and medicine, 12(3), 845-9.
Vesicle Origami and the Influence of Cholesterol on Lipid Packing
Tanasescu Radu, Lanz Martin A., Mueller Dennis, Tassler Stephanie, Ishikawa Takashi, Reiter Renate, Brezesinski Gerald, Zumbuehl Andreas (2016), Vesicle Origami and the Influence of Cholesterol on Lipid Packing, in Langmuir, 32(19), 4896-4903.
Vesicle Origami and the Influence of Cholesterol on Lipid Packing.
Tanasescu Radu, Lanz Martin A, Mueller Dennis, Tassler Stephanie, Ishikawa Takashi, Reiter Renate, Brezesinski Gerald, Zumbuehl Andreas (2016), Vesicle Origami and the Influence of Cholesterol on Lipid Packing., in Langmuir : the ACS journal of surfaces and colloids, 32(19), 4896-903.
Bilayer properties of 1,3-diamidophospholipids.
Weinberger Andreas, Tanasescu Radu, Stefaniu Cristina, Fedotenko Lllya A, Favarger France, Ishikawa Takashi, Brezesinski Gerald, Marques Carlos M, Zumbuehl Andreas (2015), Bilayer properties of 1,3-diamidophospholipids., in Langmuir : the ACS journal of surfaces and colloids, 31(6), 1879-84.
Rigid urea and self-healing thiourea ethanolamine monolayers.
Stefaniu Cristina, Zaffalon Pierre-Léonard, Carmine Alessio, Verolet Quentin, Fernandez Samuel, Wesolowski Tomasz A, Brezesinski Gerald, Zumbuehl Andreas (2015), Rigid urea and self-healing thiourea ethanolamine monolayers., in Langmuir : the ACS journal of surfaces and colloids, 31(4), 1296-302.
Translational Medicine: Nanoscience and Nanotechnology to Improve Patient Care
Müller Bert, Zumbuehl Andreas, Walter Martin A., Pfohl Thomas, Cattin Philippe C., Huwyler Jörg, Hieber Simone E. (2015), Translational Medicine: Nanoscience and Nanotechnology to Improve Patient Care, in Van de Voorde Marcel (ed.), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, 291-309.
Exit-strategies - smart ways to release phospholipid vesicle cargo
Mellal Denia, Zumbuehl Andreas (2014), Exit-strategies - smart ways to release phospholipid vesicle cargo, in JOURNAL OF MATERIALS CHEMISTRY B, 2(3), 247-252.
Conference report of the 43rd Chemistry CUSO Summer School Villars 2012: inorganic and metallosupramolecular polymers.
Kracht Sonja, Charbonnaz Pierre, Kiefer Gregor, Müller Dennis, Sobczuk Adam, Vebert-Nardin Corinne, Zaffalon Pierre-Léonard, Zumbuehl Andreas (2013), Conference report of the 43rd Chemistry CUSO Summer School Villars 2012: inorganic and metallosupramolecular polymers., in Chimia, 67(1-2), 81-3.
Monolayer Properties of 1,3-Diamidophospholipids
Fedotenko Illya A., Stefaniu Cristina, Brezesinski Gerald, Zumbuehl Andreas (2013), Monolayer Properties of 1,3-Diamidophospholipids, in LANGMUIR, 29(30), 9428-9435.
New Trends in Phospholipid Research
Zaffalon Pierre-Léonard, Zumbuehl Andreas (2013), New Trends in Phospholipid Research, in Kralchevsky Peter (ed.), CRC Press, Boca Raton, 459-473.
Phase behavior of selected artificial lipids
Zumbuehl Andreas, Dobner Bodo, Brezesinski Gerald (2013), Phase behavior of selected artificial lipids, in Current Opinion in Colloid and Interface Science, 19(1), 17-24.
Phosphate test 2.0.
Stalder Etienne, Zumbuehl Andreas (2013), Phosphate test 2.0., in Chimia, 67(11), 819-21.
Study of surfactant alcohols with various chemical moieties at the hydrophilic-hydrophobic interface
Zaffalon Pierre-Leonard, D'Anna Vincenza, Hagemann Hans, Zumbuehl Andreas (2013), Study of surfactant alcohols with various chemical moieties at the hydrophilic-hydrophobic interface, in RSC ADVANCES, 3(20), 7237-7244.
The use of shear stress for targeted drug delivery
Saxer Till, Zumbuehl Andreas, Mueller Bert (2013), The use of shear stress for targeted drug delivery, in CARDIOVASCULAR RESEARCH, 99(2), 328-333.
Clickosomes - Using triazole-linked phospholipid connectors to fuse vesicles
Loosli Frédéric, Doval David Alonso, Grassi David, Zaffalon Pierre Léonard, Favarger France, Zumbuehl Andreas (2012), Clickosomes - Using triazole-linked phospholipid connectors to fuse vesicles, in Chemical Communications, 48(10), 1604-1606.
Morphology of atherosclerotic coronary arteries
Holme Margaret N., Schulz Georg, Deyhle Hans, Hieber Simone Elke, Weitkamp Timm, Beckmann Felix, Herzen Julia, Lobrinus Johannes Alexander, Montecucco Fabrizio, Mach François, Zumbuehl Andreas, Saxer Till, Müller Bert H. (2012), Morphology of atherosclerotic coronary arteries, in Proceedings of SPIE - The International Society for Optical Engineering, 8506, 85609.
Shear stress as drug delivery trigger
Holme Margaret N., Müller Bert H., Saxer Till, Zumbuehl Andreas (2012), Shear stress as drug delivery trigger, in Chimia, 66(9), 715-715.
Shear-stress sensitive lenticular vesicles for targeted drug delivery
Holme Margaret N., Fedotenko Illya A., Abegg Daniel, Althaus Jasmin, Babel Lucille, Favarger France, Reiter Renate, Tǎnǎsescu Radu, Zaffalon Pierre Léonard, Ziegler André E., Müller Bert H., Saxer Till, Zumbuehl Andreas (2012), Shear-stress sensitive lenticular vesicles for targeted drug delivery, in Nature Nanotechnology, 7(8), 536-543.

Collaboration

Group / person Country
Types of collaboration
Prof. Dr. Bert Müller/BMC Universitätsspital Basel Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
- Exchange of personnel
- Industry/business/other use-inspired collaboration
Prof. Dr. Gerald Brezesinski/MPI Colloids and Interfaces/Potsdam Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
- Exchange of personnel
- Industry/business/other use-inspired collaboration
Prof. Dr. Carlos Marques/CNRS Charles Sadron/Strassbourg France (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
- Exchange of personnel
Sandor Balog/Uni Fribourg Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Research Infrastructure
Prof. Dr. Jan Behrends Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
Dr. Till Saxer/Hôpitaux Universitaires de Genève Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
- Exchange of personnel
- Industry/business/other use-inspired collaboration
Prof. Dr. Aurélien Roux Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
- Exchange of personnel
Christophe Danelon/TU Delft Netherlands (Europe)
- in-depth/constructive exchanges on approaches, methods or results
Dr. Renate Reiter/Institute of Physics, Universität Freiburg i.B. Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
- Exchange of personnel
Takashi Ishikawa, PSI Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
COST CM1304 Meeting Talk given at a conference From amphiphilic molecuels to spherical and cubic lipid vesicles 30.03.2017 Warszawa, Poland Zumbühl Andreas;
33th Meeting of the Schweizerische Arbeitsgemeinschaft Oberflächen und Grenzflächen Talk given at a conference Monolayer and Bilayer Properties of a 1,2-Diamidophospholipid 27.01.2017 Fribourg, Switzerland Zumbühl Andreas;
Trends in Nanotechnology 2016 Talk given at a conference Vesicle Origami 05.09.2016 University of Fribourg, Switzerland Zumbühl Andreas; Tanasescu Radu;
30th Meeting of the European Colloids and Interface Society Talk given at a conference Vesicle Origami 04.09.2016 Rome, Italy Zumbühl Andreas;
30th Meeting of the European Colloids and Interface Society Talk given at a conference A Mechanosensitive Hydrogel 04.09.2016 Rome, Italy Stalder Etienne;
SoMAs Summer School Talk given at a conference Membrane stabilization through bilayer interdigitation and its effects on phospholipid vesicle morphology 03.07.2016 Mittlewihr, France Zumbühl Andreas;
Pharmaziekolloquium Individual talk Vesikel Origami - Synthese und Anwendungen künstlicher Phospholipide 25.05.2016 University of Halle, Germany Zumbühl Andreas;
Seminar of the Institute of Food, Nutrition and Health Individual talk Vesicle Origami with Artificial Lipids 17.11.2015 ETH Zürich, Switzerland Zumbühl Andreas;
21. Ostwald Kolloquium Talk given at a conference Rigid Urea and Self-Healing Thiourea Ethanolamine Monolayers 29.09.2015 University of Potsdam, Germany Zumbühl Andreas;
NCCR Bio-inspired Materials Centre Conference Talk given at a conference Addressing the Temporomandibular Joint Disorder
 14.09.2015 Murten, Switzerland Zumbühl Andreas; Stalder Etienne;
Fallmeeting Swiss Chemical Society Poster Why are Vesicles of the Artificial 1,3-Diamidophosholipid Pad-PC-Pad Mechanosensitive? 04.09.2015 Lausanne, Switzerland Müller Dennis;
PolyColl Meeting of the Swiss Chemical Society Poster Mechanosensitivity as Trigger in Targeted Drug Delivery 03.07.2015 Fribourg, Switzerland Müller Dennis;
FriMat Meeting Talk given at a conference Shear-sensitive Vesicles for Targeted Drug Delivery 02.07.2015 Fribourg, Switzerland Müller Dennis;
8th Clinical Nanomedicine Conference Talk given at a conference Mechanosensitive Vesicles for Targeting Critically Stenosed Arteries 29.06.2015 Basel, Switzerland Zumbühl Andreas;
Swiss Society for Biomaterials and Regenerative Medicine Meeting Poster Amido, urea and thiourea ethanolamine monolayers 09.06.2015 Lausanne, Switzerland Müller Dennis;
15th Meeting of the International Association of Colloid and Interface Scientists Talk given at a conference Shear-Stress Responsive Liposomes 28.05.2015 Mainz, Germany Zumbühl Andreas;
COST CM1304 Annual Meeting Talk given at a conference Shear-Stress Responsive Liposomes 21.05.2015 Rolduc, Netherlands Zumbühl Andreas;
Geneva Chemical Society Individual talk Vesicle Origami 11.05.2015 Geneva, Switzerland Zumbühl Andreas;
COST CM1304 group meeting Talk given at a conference Shear-sensitive vesicles 21.11.2014 Pullach, Germany Zumbühl Andreas;
IRTG Seminar University of Freiburg Individual talk Mechanosensitive Phospholipid Vesicles - Balance of Forces at Play 05.11.2014 Freiburg, Germany Zumbühl Andreas;
Department Talk University of Neuchâtel Individual talk Artificial Phospholipids - Synthesis, Biophysics, and Applications 29.10.2014 Neuchâtel, Switzerland Zumbühl Andreas;
Swiss Japanese Symposium Poster Shear-sensitive 1,3-Diamidophospholipid Liposomes, a new Class in Targeted Drug Delivery 02.10.2014 Basel, Switzerland Müller Dennis;
Fallmeeting Swiss Chemical Society Poster 1,3-Diamidophospholipids and Analogous Lipids: Synthesis and Characterization 11.09.2014 Zürich, Switzerland Müller Dennis;
European Colloids and Interface Science Conference Talk given at a conference Phospholipid Test 2.0 07.09.2014 Limmasol, Cyprus Stalder Etienne;
Meeting of the Swiss Physical Society Talk given at a conference Balance of Forces at Play in Phospholipid Self-Assembly 02.07.2014 Fribourg, Switzerland Zumbühl Andreas;
ICPC Poster Synthesis and Properties of 1,3-Diamidophospholipids and Analogous Lipids 28.06.2014 Dublin, Ireland Müller Dennis;
Surfactants in Solution Talk given at a conference Balance of Forces at Play in Phospholipid Self-Assembly 25.06.2014 Coimbra, Portugal Zumbühl Andreas;
Invited Lecture Individual talk Shear Stress Sensitive Vesicles for Targeted Drug Delivery. 24.06.2014 Biocant (Center of Innovation and Biotechnology) Cantanhede, Portugal Zumbühl Andreas;
Bürgenstock Conference Poster Mechano-sensitive vesicles for Targeted Drug Delivery 04.05.2014 Brunnen, Switzerland Zumbühl Andreas;
Seminars on Drug Discovery and Development Individual talk Shear Stress Sensitive Vesicles for Targeted Drug Delivery 26.03.2014 Pharmazentrum Basel, Switzerland Zumbühl Andreas;
COST workshop: Interactions in Colloidal Systems Talk given at a conference Phase Behavior of Selected Artificial Lipids 24.03.2014 Technische Universität, Berlin, Germany Zumbühl Andreas;
Swiss Soft Days 12 Poster Artificial Phospholipids 14.10.2013 Bern, Switzerland Stalder Etienne;
Graduate Student Symposium Bern-Fribourg-Neuchatel Talk given at a conference Artificial Phospholipids 09.09.2013 Bern, Switzerland Stalder Etienne; Müller Dennis; Tanasescu Radu;
Soft Matter Summer School IRTG Poster Artificial Phospholipids 08.07.2013 Mittelwihr, France Tanasescu Radu;
50years of Erick Carreira Talk given at a conference Artificial Phospholipids 04.07.2013 Zürich, Switzerland Zumbühl Andreas;
Cost Meeting CM1106 Talk given at a conference Forces at Play in Phospholipid Self-assembly 01.04.2013 Nicosia, Cyprus Zumbühl Andreas;
Select Bio Discovery Chemistry Congress Talk given at a conference Shear-stress Sensitive Vesicles for Targeted Drug Delivery 19.03.2013 München, Germany Zumbühl Andreas;
17th Rencontre Pharmapeptides Talk given at a conference Shear-stress Sensitive Vesicles for Targeted Drug Delivery 16.11.2012 Anchamps, France Zumbühl Andreas;
Fribourg Chemical Society Individual talk Shake up and get back into shape! Introductory Lecture 13.11.2012 Fribourg, Switzerland Zumbühl Andreas;
GTC Drug Delivery and Technology Talk given at a conference Shear-stress Sensitive Nanocontainers for Targeted Drug Delivery 06.09.2012 Zürich, Switzerland Zumbühl Andreas;


Self-organised

Title Date Place
Swiss Soft Days 11 04.06.2013 Fribourg, Switzerland

Knowledge transfer events

Active participation

Title Type of contribution Date Place Persons involved
GIF/VFI event Talk 05.12.2013 Fribourg, Switzerland Zumbühl Andreas;
2. Nationale Konferenz Uebergang Gymnasium-Hochschule Workshop 02.09.2013 Lausanne, Switzerland Zumbühl Andreas;


Communication with the public

Communication Title Media Place Year
Talks/events/exhibitions Chemieshow Novartis Science Day 2016 German-speaking Switzerland 2016
Talks/events/exhibitions i-net Nano Technology Event German-speaking Switzerland 2016
Other activities kids Uni Fribourg Western Switzerland 2016
Talks/events/exhibitions Vesicle Origami Western Switzerland 2015
Talks/events/exhibitions Zentralkurs der Schweizer Naturwissenschaftslehrpersonen German-speaking Switzerland 2015
Talks/events/exhibitions Chemieshow Bulle Western Switzerland 2014
Talks/events/exhibitions Chemistry show for local school Western Switzerland 2014
Media relations: radio, television Mit Nanotechnologie gegen Arterienverkalkung SRF 1 Gesundheit Sprechstunde German-speaking Switzerland 2014
Talks/events/exhibitions NO Stress! - Mechanosensitive Drug Delivery Western Switzerland 2014
Talks/events/exhibitions Open House Day Chemistry/Physics Departments Uni Fribourg Western Switzerland German-speaking Switzerland 2014
Other activities Chemieshow Novartis Science Day 2013 German-speaking Switzerland 2013

Associated projects

Number Title Start Funding scheme
166209 Exploring Stable Phospholipid Membranes 01.08.2016 SNSF Professorships

Abstract

Liposomes are well established elements of modern nanomedicine. However, the next innovative boost is only possible if several of the old design restrictions are overthrown: 1. Vesicles do not need to be spherical. We make non-spherical liposomes with broader mechanical properties. 2. Vesicles do not need to be formulated from chemically stable phospholipids. We synthesize li- posomes with highly reactive surfaces. 3. Vesicles do not need to be administered intravenously or topically. We design liposomes to address medical problems such as osteoarthritis.
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