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NO-Stress, a specific coronary vasodilator - nano-container for tailored NO release

English title NO-Stress, a specific coronary vasodilator - nano-container for tailored NO release
Applicant Müller Bert
Number 126090
Funding scheme NRP 62 Smart Materials
Research institution Zentrum für Lehre und Forschung Kantonsspital Basel Onkologie
Institution of higher education University of Basel - BS
Main discipline Cardiovascular Research
Start/End 01.02.2010 - 28.02.2015
Approved amount 616'978.00
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All Disciplines (6)

Discipline
Cardiovascular Research
Other disciplines of Physics
Biochemistry
Organic Chemistry
Clinical Cardiovascular Research
Pharmacology, Pharmacy

Keywords (5)

nanomedicine; liposomes; shear stress; stenosis; cardiovascular

Lay Summary (German)

Lead
Das interdisziplinäre Projekt NO-Stress verpackt das gefässerweiternde Medikament (Nitroglyzerin) in wie Linsen geformte Nanocontainer, die sich wegen ihrer Form erst an verengten Blutgefässen aufgrund der erhöhten Scherkräfte öffnen, genau dort, wo die Wirkung benötigt wird. Damit bleiben die gesunden Gefässe weitgehend unberührt und Nebenwirkungen wie der Blutdruckabfall gebannt. NO-stress ist ein Wortspiel mit dem chemischen Kürzel des bei Gefässerweiterung wirkenden Stickoxids NO.
Lay summary

Atherosklerose ist heute Todesursache Nummer 1. Wir entwickeln eine effektive Behandlung dieser Krankheit mittels Nanocontainern, die ihren Inhalt bevorzugt an den Verengungen der Blutgefässe freisetzen.

Hintergrund: Nanotechnologie erlaubt die gezielte Freisetzung durch chemische Wechselwirkungen. Jetzt kann man auch physikalische  Steuerungsimpulse benutzen, um Medikamente beispielsweise an den Verengungen der Blutgefässe freizusetzen. Hier kann man die Scherspannungen in den Blutgefässen herrschen und bei den Verengungen etwa 10mal grösser als in den gesunden Gefässen sind.

Ziel ist die Entwicklung von scherspannungssensitiven Nanocontainern.

Signifikanz: Atherosklerose ist heute Todesursache Nummer 1. Ein Herzinfarkt hat schwere Folgen für die Gesundheit und die Lebensqualität der Betroffenen. Kann man schnell reagieren und die betroffenen Blutgefässe entsprechend öffnen und damit den gewohnten Blutfluss wiederherstellen, so kann man das Patientenrisiko erheblich senken.

Anwendung: Wir haben ein Modell entwickelt, mit dessen Hilfe man die Freisetzung an den Verengungen der künstlichen Blutgefässe experimentell messen kann. So konnten wir zeigen, dass das Prinzip umsetzbar ist. Nun müssen Formulierungen gefunden werden, die praxistauglich sind, d.h. klinische Studien erlauben.

Direct link to Lay Summary Last update: 12.07.2013

Responsible applicant and co-applicants

Employees

Publications

Publication
Bilayer properties of 1,3-diamidophospholipids
Weinberger Andreas, Tanasescu Radu, Stefaniu Cristina, Fedotenko Lllya A., Favarger France, Ishikawa Takashi, Brezesinski Gerald, Marques Carlos M., Zumbuehl Andreas, Zumbuehl Andreas (2015), Bilayer properties of 1,3-diamidophospholipids, in Langmuir, 31(6), 1879-1884.
Rigid urea and self-healing thiourea ethanolamine monolayers.
Stefaniu Cristina, Zaffalon Pierre-Léonard, Carmine Alessio, Verolet Quentin, Fernandez Samuel, Wesolowski Tomasz A, Brezesinski Gerald, Zumbuehl Andreas (2015), Rigid urea and self-healing thiourea ethanolamine monolayers., in Langmuir : the ACS journal of surfaces and colloids, 31(4), 1296-302.
Translational medicine: Nanoscience and -technology to improve patient care
Müller B., Zumbuehl A., Walter M.A., Pfohl T., Cattin P.C., Huwyler J., Hieber S.E. (2015), Translational medicine: Nanoscience and -technology to improve patient care, in Fecht H. (ed.), Wiley-VCH, Weinheim, 291-309.
Comparing microfluidic devices and established glass capillaries in laboratory-based X-ray scattering of liposomes as nano-containers for drug delivery
Buscema Marzia, Pfohl Thomas, Zumbuehl Andreas, Müller Bert (2014), Comparing microfluidic devices and established glass capillaries in laboratory-based X-ray scattering of liposomes as nano-containers for drug delivery, in Swiss Society for Biomaterials and Regenerative Medicine, 28(Suppl. 6), 26.
Complementary X-ray tomography techniques for histology-validated 3D imaging of soft and hard tissues using plaque-containing blood vessels as examples.
Holme Margaret N, Schulz Georg, Deyhle Hans, Weitkamp Timm, Beckmann Felix, Lobrinus Johannes A, Rikhtegar Farhad, Kurtcuoglu Vartan, Zanette Irene, Saxer Till, Müller Bert (2014), Complementary X-ray tomography techniques for histology-validated 3D imaging of soft and hard tissues using plaque-containing blood vessels as examples., in Nature protocols, 9(6), 1401-15.
Exit-strategies - smart ways to release phospholipid vesicle cargo
Mellal Denia, Zumbuehl Andreas (2014), Exit-strategies - smart ways to release phospholipid vesicle cargo, in JOURNAL OF MATERIALS CHEMISTRY B, 2(3), 247-252.
Grating interferometry-based phase microtomography of atherosclerotic human arteries
Buscema Marzia, Holme Margaret N., Deyhle Hans, Schulz Georg, Schmitz Rüdiger, Thalmann Peter, Hieber Simone E., Chicherova Natalia, Chicherova Natalia, Beckmann Felix, Herzen Julia, Weitkamp Timm, Saxer Till, Müller Bert (2014), Grating interferometry-based phase microtomography of atherosclerotic human arteries, in Proceedings of SPIE - The International Society for Optical Engineering, 9212, 921203.
Immune complement activation by a faceted nano-container in the pig model
Bugna Simon, Weinberger Andreas, Urbanics Rudolf, Müller Bert, Zumbuehl Andreas, Szebeni Janos, Saxer Till (2014), Immune complement activation by a faceted nano-container in the pig model, in Swiss Society for Biomaterials and Regenerative Medicine, 28(Suppl. 6), 5.
Monolayer properties of 1,3-diamidophospholipids
Fedotenko Lllya A., Stefaniu Cristina, Brezesinski Gerald, Zumbuehl Andreas (2013), Monolayer properties of 1,3-diamidophospholipids, in Langmuir, 29(30), 9428-9435.
Phase behavior of selected artificial lipids
Zumbuehl Andreas, Zumbuehl Andreas, Dobner Bodo, Brezesinski Gerald (2013), Phase behavior of selected artificial lipids, in Current Opinion in Colloid and Interface Science, 19(1), 17-24.
Study of surfactant alcohols with various chemical moieties at the hydrophilic-hydrophobic interface
Zaffalon Pierre-Leonard, D'Anna Vincenza, Hagemann Hans, Zumbuehl Andreas (2013), Study of surfactant alcohols with various chemical moieties at the hydrophilic-hydrophobic interface, in RSC ADVANCES, 3(20), 7237-7244.
The use of shear stress for targeted drug delivery
Saxer Till, Zumbuehl Andreas, Müller Bert (2013), The use of shear stress for targeted drug delivery, in Cardiovascular Research, 99(2), 328-333.
Grating-based tomography of human tissues
Müller Bert, Schulz Georg, Mehlin Andrea, Herzen Julia, Herzen Julia, Lang Sabrina, Holme Margaret, Zanette Irene, Zanette Irene, Hieber Simone, Deyhle Hans, Beckmann Felix, Pfeiffer Franz, Weitkamp Timm, Weitkamp Timm (2012), Grating-based tomography of human tissues, in AIP Conference Proceedings, 1466, 107-112.
Morphology of atherosclerotic coronary arteries
Holme Margaret N., Holme Margaret N., Holme Margaret N., Schulz Georg, Deyhle Hans, Hieber Simone Elke, Weitkamp Timm, Beckmann Felix, Herzen Julia, Lobrinus Johannes A., Montecucco Fabrizio, Mach François, Zumbuehl Andreas, Saxer Till, Müller Bert (2012), Morphology of atherosclerotic coronary arteries, in Proceedings of SPIE - The International Society for Optical Engineering, 8506, 850609.
Shear stress as drug delivery trigger
Holme Margaret N., Holme Margaret N., Holme Margaret N., Müller Bert, Saxer Till, Zumbuehl Andreas (2012), Shear stress as drug delivery trigger, in Chimia, 66(9), 715-715.
Shear-stress sensitive lenticular vesicles for targeted drug delivery
Holme Margaret N., Holme Margaret N., Holme Margaret N., Fedotenko Illya A., Abegg Daniel, Althaus Jasmin, Babel Lucille, Favarger France, Reiter Renate, Tanasescu Radu, Zaffalon Pierre Léonard, Ziegler André, Müller Bert, Saxer Till, Zumbuehl Andreas (2012), Shear-stress sensitive lenticular vesicles for targeted drug delivery, in Nature Nanotechnology, 7(8), 536-543.
Was ist Nano-Medizin? - Nanotechnologie zum Wohl der Patienten!
Müller Bert (2012), Was ist Nano-Medizin? - Nanotechnologie zum Wohl der Patienten!, in Rev. Méd. Suisse , 8, 152-153.
Aktuelle medizinische Forschungsaktivitäten am Biomaterials Science Center der Universität Basel
Müller Bert (2011), Aktuelle medizinische Forschungsaktivitäten am Biomaterials Science Center der Universität Basel, in Swiss Review of Military and Disaster Medicine: Neue Technologien in der Medizin , 2, 34-35.
Putting the 'P' into phospholipids
Fedotenko Illya A., Holme Margaret N., Tanasescu Radu, Zaffalon Pierre Léonard, Zumbuehl Andreas (2011), Putting the 'P' into phospholipids, in Chimia, 65(11), 859-862.
Shear stress sensitive nanocontainers for targeted drug delivery
Holme M. N., Holme M. N., Holme M. N., Zumbuehl A., Saxer T., Müller B. (2011), Shear stress sensitive nanocontainers for targeted drug delivery, in European Cells and Materials, 22(SUPPL.4), 35-35.
Imaging of Human Coronary Arteries
Holme M., Beckmann F., Müller-Gerbl M., Püschel K., Müller B. (2010), Imaging of Human Coronary Arteries, HASYLAB, DESY, Hamburg.

Collaboration

Group / person Country
Types of collaboration
HASYLAB, DESY Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
University of Geneva Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
University Hospital Zürich Switzerland (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure
University Hospital Hamburg Germany (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
ESRF Grenoble France (Europe)
- in-depth/constructive exchanges on approaches, methods or results
- Publication
- Research Infrastructure

Scientific events

Active participation

Title Type of contribution Title of article or contribution Date Place Persons involved
15th Meeting of the International Association of Colloid and Interface Scientists Talk given at a conference Shear-Stress Responsive Liposomes 28.05.2015 Mainz, Germany Zumbühl Andreas;
COST CM1304 Annual Meeting Talk given at a conference Shear-Stress Responsive Liposomes 21.05.2015 Rolduc, Netherlands Zumbühl Andreas;
Geneva Chemical Society Talk given at a conference Vesicle Origami 11.05.2015 Geneva, Switzerland Zumbühl Andreas;
Meeting of the Chemistry Alumni of the University of Fribourg Talk given at a conference Vesicle Origami 02.05.2015 Fribourg, Switzerland Zumbühl Andreas;
Site visit of the NCCR Bio-inspired Materials Talk given at a conference Vesicle-containing Metallosupramolecular Polymers 27.04.2015 Fribourg, Switzerland Zumbühl Andreas;
Imaging Seminar (invited talk) Individual talk Hard X-ray imaging of biomaterials and human tissues 10.04.2015 Diamond Light Source, Great Britain and Northern Ireland Müller Bert;
DESY Photon Science Users' Meeting 2015 Poster Complementary X-ray tomography techniques for histology-validated 3D imaging of soft and hard tissues using plaque-containing blood vessels as example 29.01.2015 Hamburg, Germany Schulz Georg; Müller Bert; Buscema Marzia Maria Gaia; Holme Margaret; Saxer Till;
IMXP 2015 Poster Complementary X-ray tomography techniques for histology-validated 3D imaging of soft and hard tissues using plaque-containing blood vessels as example 29.01.2015 Garmisch-Partenkirchen, Germany Buscema Marzia Maria Gaia; Müller Bert; Saxer Till; Schulz Georg;
COST CM1304 group meeting Talk given at a conference Shear-sensitive Vesicles 21.11.2014 Pullach, Germany Zumbühl Andreas;
2 h general lecture for French speaking Swiss highschool teachers Individual talk Biomedicine – Definition, Concepts, Applications 19.11.2014 Fribourg, Switzerland Zumbühl Andreas;
After-Dinner Talk Studienstiftung Schweiz Individual talk NO Stress! – Mechanosensitive Drug Delivery 13.11.2014 Fribourg, Switzerland Zumbühl Andreas;
IRTG Seminar Talk given at a conference Mechanosensitive Phospholipid Vesicles – Balance of Forces at Play 05.11.2014 University of Freiburg, Germany Zumbühl Andreas;
University of Neuchâtel Individual talk Artificial Phospholipids – Synthesis, Biophysics, and Applications 29.10.2014 University of Neuchâtel, Switzerland Zumbühl Andreas;
International Conference on X-Ray Microscopy Poster X-ray microscopy of soft and hard human tissues 26.10.2014 Melbourne, Australia Schulz Georg; Holme Margaret; Müller Bert;
Japan-Switzerland Workshop on Biomechanics Poster Determining the Shear Stress Threshold of Mechano-Sensitive Nanocontainers for Targeted Vasodilatation 01.09.2014 Shima, Japan Buscema Marzia Maria Gaia; Bugna Simon; Saxer Till; Zumbühl Andreas; Weinberger Andreas; Holme Margaret; Müller Bert;
Developments in X-Ray Tomography IX Talk given at a conference Grating interferometry-based phase microtomography of atherosclerotic human arteries 18.08.2014 San Diego, United States of America Buscema Marzia Maria Gaia; Saxer Till; Schulz Georg; Müller Bert;
Swiss Physical Society Annual Meeting Talk given at a conference Balance of Forces at Play in Phospholipid Self-Assembly 02.07.2014 University of Fribourg, Switzerland Zumbühl Andreas;
20th Surfactants in Solution Meeting Talk given at a conference Balance of Forces at Play in Phospholipid Self-Assembly 25.06.2014 University of Coimbra, Portugal Zumbühl Andreas;
Biocant (Center of Innovation and Biotechnology) Cantanhede Individual talk Shear Stress Sensitive Vesicles for Targeted Drug Delivery 24.06.2014 University of Coimbra, Portugal Zumbühl Andreas;
Materials meet medicine Talk given at a conference Research at the Biomaterials Science Center – an overview 10.06.2014 Berlin, Germany Weinberger Andreas; Schulz Georg; Müller Bert; Holme Margaret; Saxer Till; Zumbühl Andreas; Buscema Marzia Maria Gaia; Bugna Simon;
Materials meet medicine Talk given at a conference The complement immunity activation by a faceted nano-container in the pig model 10.06.2014 Burg, Germany Weinberger Andreas; Saxer Till; Zumbühl Andreas; Müller Bert; Buscema Marzia Maria Gaia; Bugna Simon;
Materials meet medicine Talk given at a conference Atherosclerosis: Disease development and measures for its prevention 10.06.2014 Burg, Germany Holme Margaret;
Science 3D Workshop Talk given at a conference SRµCT of human tissues, medical implants, and their interfaces 02.06.2014 Hamburg, Germany Müller Bert;
20th Annual Meeting of the Swiss Society for Biomaterials and Regenerative Medicine Talk given at a conference CARPA ACTIVATION OF A FACETED NANO-CONTAINER IN A PIG MODEL 07.05.2014 Basel, Switzerland Bugna Simon; Müller Bert; Saxer Till; Zumbühl Andreas; Weinberger Andreas;
20th Annual Meeting of the Swiss Society for Biomaterials and Regenerative Medicine Poster COMPARING MICROFLUIDIC DEVICES AND ESTABLISHED GLASS CAPILLARIES IN LABORATORY-BASED X-RAY SCATTERING AT LIPOSOMES TO OPTIMIZE TARGETED DRUG DELIVERY 07.05.2014 Basel, Switzerland Müller Bert; Buscema Marzia Maria Gaia; Zumbühl Andreas;
Seminars on Drug Discovery and Development Individual talk Shear Stress Sensitive Vesicles for Targeted Drug Delivery 26.03.2014 Pharmazentrum Basel, Switzerland Zumbühl Andreas;
NRP62 Second-phase Kick-off Meeting Talk given at a conference Shear-stress Sensitive Vesicles for Targeted Drug Delivery 30.05.2013 Löwenberg, Switzerland Müller Bert; Zumbühl Andreas; Saxer Till;
Select Bio Discovery Chemistry Congress Talk given at a conference Shear-stress Sensitive Vesicles for Targeted Drug Delivery 19.03.2013 München, Germany Zumbühl Andreas;
Nanoscale Photonic Imaging SFB 755 Individual talk Hard X-ray imaging of human tissuesdown to the nanometer scale 10.01.2013 Göttingen, Germany Müller Bert;
17th Rencontre Pharmapeptides Talk given at a conference Shear-stress Sensitive Vesicles for Targeted Drug Delivery 16.11.2012 Archamps, France Zumbühl Andreas;
Synchrotron SOLEIL Individual talk Mechanosensitive nano-containers for targeted drug deliveryin atherosclerosis: the importance to image vessel morphology 12.10.2012 Gif-sur-Yvette, France Holme Margaret;
Swiss Chemical Society Fall Meeting Poster Shear-stress Sensitive Vesicles for Targeted Drug Delivery 13.09.2012 Zurich, Switzerland, Switzerland Zumbühl Andreas; Holme Margaret;
5th European Conference for Clinical Nanomedicine (CLINAM) Talk given at a conference Shear-stress Sensitive Vesicles for Targeted Drug Delivery 07.09.2012 Basel, Switzerland, Switzerland Zumbühl Andreas; Müller Bert; Saxer Till;
GTC Drug Delivery and Technology Talk given at a conference Shear-stress Sensitive Vesicles for Targeted Drug Delivery 06.09.2012 Zurich, Switzerland, Switzerland Zumbühl Andreas;
SPIE 2012 Talk given at a conference Morphology of atherosclerotic human coronary arteries 13.08.2012 San Diego, CA, USA, United States of America Müller Bert; Holme Margaret; Saxer Till; Zumbühl Andreas; Schulz Georg;
SoMaS Summer School Talk given at a conference Shear-stress Sensitive Vesicles for Targeted Drug Delivery 06.07.2012 Mittelwihr, France, France Zumbühl Andreas;
9th International Conference on Nanosciences and Nanotechnologies (NN12) Talk given at a conference Shear-stress sensitive lenticular vesicles for targeted drug delivery 02.07.2012 Thessaloniki, Greece, Greece Müller Bert; Saxer Till; Zumbühl Andreas; Holme Margaret;
Swiss Soft Days Poster Shear-stress Sensitive Vesicles for Targeted Drug Delivery 12.06.2012 Geneva, Switzerland, Switzerland Holme Margaret; Zumbühl Andreas;
9th World Biomaterials Congress (WBC) Poster Shear Stress Sensitive Vesicles for Targeted Vasodilator Delivery 01.06.2012 Chengdu, China, China Müller Bert; Zumbühl Andreas; Saxer Till; Holme Margaret;
International Workshop on X-ray and Neutron Phase Imaging with Gratings (XNPIG) Talk given at a conference Grating-based tomography of human tissues 05.03.2012 Tokyo, Japan, Japan Schulz Georg; Müller Bert; Holme Margaret;
Ärztekongress Quadrimed Talk given at a conference Was ist Nano-Medizin?Nanotechnologie zum Wohl der Patienten! 27.01.2012 Crans-Montana, Switzerland Müller Bert;
Swiss Chemical Society Fall Meeting 2011 Poster Shear-stress Sensitive Vesicles for Targeted Drug Delivery. 09.11.2011 EPFL Lausanne, Switzerland, Switzerland Holme Margaret;
Meeting of the Rheology and Nanoscience Group Basel Individual talk Shear-stress Sensitive Vesicles for Targeted Drug Delivery 08.11.2011 Muttenz, Switzerland, Switzerland Müller Bert; Zumbühl Andreas;
Nachwuchswissenschaftertagung Bioorganik Talk given at a conference Shear-stress Sensitive Vesicles for Targeted Drug Delivery 26.09.2011 Karlsruhe, Germany, Switzerland Zumbühl Andreas;
Schweizerische Gesellschaft der Offiziere der Sanitätstruppen Internationale Tagung Talk given at a conference CMBE Basel: Forschung fur Medizin und Zahnmedizin 17.09.2011 Basel, Switzerland, Switzerland Müller Bert;
European Colloids and Interface Society ECIS Poster Shear-stress Sensitive Vesicles for Targeted Drug Delivery. 04.09.2011 Berlin, Germany, Germany Zumbühl Andreas;
NRP 62 Meeting Talk given at a conference Shear-stress Sensitive Vesicles for Targeted Drug Delivery 22.08.2011 Fribourg, Switzerland, Switzerland Saxer Till; Müller Bert; Zumbühl Andreas;
NRP 62 Workshop Talk given at a conference Shear-stress Sensitive Vesicles for Targeted Drug Delivery 23.05.2011 Lugano, Switzerland, Switzerland Müller Bert;
4th European Conference for Clinicam Nanomedicine (CLINAM) Talk given at a conference Shear-stress Sensitive Vesicles for Targeted Drug Delivery 23.05.2011 Basel, Switzerland, Switzerland Holme Margaret; Saxer Till; Zumbühl Andreas; Müller Bert;
17th Swiss Conference on Biomaterials (SSB 2011) Poster Shear-stress Sensitive Vesicles for Targeted Drug Delivery 04.05.2011 Yverdon-les-Bains, Switzerland, Switzerland Müller Bert; Holme Margaret; Zumbühl Andreas;
COST D43 Talk given at a conference Synthesis and Applications of Artificial Phospholipids 30.03.2011 Madrid, Spain, Spain Zumbühl Andreas;
Chemiedozententagung Talk given at a conference Synthesis and Applications of Artificial Phospholipids 14.03.2011 Mainz, Germany, Germany Zumbühl Andreas;
3rd European Conference for Clinicam Nanomedicine (CLINAM) Poster Shear-stress Sensitive Vesicles for Targeted Drug Delivery 10.05.2010 Basel, Switzerland, Switzerland Müller Bert; Saxer Till; Zumbühl Andreas; Holme Margaret;


Knowledge transfer events

Active participation

Title Type of contribution Date Place Persons involved
Journée de l'Innovation Talk 19.10.2011 University Hospitals of Geneva, Switzerland Müller Bert; Zumbühl Andreas; Saxer Till;


Communication with the public

Communication Title Media Place Year
Media relations: radio, television Mit Nanotechnologie gegen Arterienverkalkung SRF Gesundheit heute German-speaking Switzerland 2014
New media (web, blogs, podcasts, news feeds etc.) Fighting Cardiovascular Disease With A 'Time Bomb'Developed By Researchers Medical News Today International 2012
Talks/events/exhibitions Können Forscher des BMC helfen, Fragen am Museum zu beantworten? German-speaking Switzerland 2012
New media (web, blogs, podcasts, news feeds etc.) Researchers develop a 'time bomb' to fight cardiovascular disease International 2012
Media relations: radio, television RTS info report in news Rhaeto-Romanic Switzerland 2012
New media (web, blogs, podcasts, news feeds etc.) Verengte Blutgefässe: Basler und Genfer Forscher entwickeln Nanocontainer International 2012
New media (web, blogs, podcasts, news feeds etc.) Verengte Blutgefässe: Basler und Genfer Forscher entwickeln Nanocontainer International 2011

Awards

Title Year
Best Poster at CLINAM 2012 2012
Young Reseach's Award at NN12 2012

Associated projects

Number Title Start Funding scheme
133802 Micro- and Nanotomography 01.03.2011 R'EQUIP
150164 Multi-modal matching of two-dimensional images with three-dimensional data in the field of biomedical engineering 01.11.2013 Project funding

Abstract

Ziel des interdisziplinären Projekts NO-Stress ist es, ein gefässerweiterndes Medikament (Nitroglyzerin) in wie Linsen geformte Nanocontainer zu verpacken, die sich wegen ihrer Form erst an den verengten Blutgefässen aufgrund der erhöhten Scherkräfte öffnen. Sie sollen sich also genau dort öffnen, wo die Wirkung benötigt wird und die gesunden Gefässe weitgehend unberührt lassen. Damit bleiben Nebenwirkungen wie beispielsweise der Blutdruckabfall gebannt. NO-stress ist ein Wortspiel mit dem chemischen Kürzel des bei Gefässerweiterung wirkenden Sickoxids NO.
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