Institute

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Name

Département de Pharmacologie & Toxicologie Faculté de Biologie et de Médecine Université de Lausanne

Address Département de Pharmacologie & Toxicologie Faculté de Biologie et de Médecine Université de Lausanne
Rue du Bugnon 27
1011
CH-Lausanne
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Projects

Responsible applicant Institution of higher education Start End date Funding scheme

Regulation of epithelial Na(+) transport: implication of controlled ubiquitylation and ER-associated degradation
Staub Olivier University of Lausanne - LA 01.04.2009 31.03.2012 Project funding

The role of A-kinase anchoring proteins in cardiac protection
Diviani Dario University of Lausanne - LA 01.10.2011 30.09.2014 Project funding

The epithelial sodium channel: role in mediating aldosterone- dependent sodium transport and in controlling blood pressure
Rossier Bernard C. University of Lausanne - LA 01.10.1995 30.09.2000 Project funding

Organisation of Membrane Polarity in Epithelial Cells, EMBO Workshop
Rossier Bernard C. University of Lausanne - LA 01.04.1982 31.12.1982 Scientific Conferences

The epithelial sodium channel (ENaC): Activation by membrane bound serine proteases
Rossier Bernard C. University of Lausanne - LA 01.10.2005 31.03.2009 Project funding

Dissecting the CAP1-PAR2-TSLP pathway in tight epithelial cells
Hummler Edith University of Lausanne - LA 01.10.2012 30.09.2015 Project funding

Toxicité rénale et transport tubulaire du cadmium chez le mammifère
Diezi Jacques University of Lausanne - LA 01.10.1982 30.09.1984 Project funding

Transports transépithéliaux lors du développement tubulaire et après néphrectomie unilatérale.
Diezi Jacques University of Lausanne - LA 01.04.1979 31.03.1981 Project funding

Characterization and localization of protein molecules transporting organic ions and of Na+-K+-ATPase
Roch-Ramel Françoise University of Lausanne - LA 01.04.1983 31.03.1986 Project funding

Inducible nitric oxide synthase (INOS): role in differentiation and genotoxicity in epithelial cells
Felley-Bosco Emanuela University of Lausanne - LA 01.04.1997 31.08.1999 Project funding

The role of A-kinase anchoring proteins in cardiac healing and repair
Diviani Dario University of Lausanne - LA 01.10.2017 30.09.2022 Project funding

Elucidation of the mutagenic pathway of heterocyclic amines, a class of common food contaminants, in human cells
Morgenthaler-Leong Phaik-Mooi University of Lausanne - LA 01.10.1997 30.09.2000 Project funding

Molecular physiology of ENaC-mediated sodium transport in skin and lung epithelium
Hummler Edith University of Lausanne - LA 01.04.2001 30.09.2003 Project funding

Glucose transporters and central glucodetection
Thorens Bernard University of Lausanne - LA 01.10.2001 30.09.2006 Project funding

Toxicité rénale et transport tubulaire du cadmium chez le mammifère
Diezi Jacques University of Lausanne - LA 01.10.1984 31.03.1987 Project funding

Molecular mechanism and regulation of potassium transport
Schild Laurent University of Lausanne - LA 01.10.2006 30.09.2010 Project funding

Mechanisms involved in cellular transport of organic and inorganic ions and their regulation
Roch-Ramel Françoise University of Lausanne - LA 01.04.1986 31.03.1989 Project funding

EMBO workshop on structure, function and regulation of membrane transport proteins
Rossier Bernard C. University of Lausanne - LA 01.04.1987 30.09.1987 Scientific Conferences

Rational drug design to target Wnt signaling in triple-negative breast cancer
Katanaev Vladimir University of Lausanne - LA 01.10.2015 30.09.2018 ERA.Net RUS Plus

Toxicité épithéliale et rénale de métaux lourds et autres substances chimiques
Diezi Jacques University of Lausanne - LA 01.04.1989 31.03.1992 Project funding

Epithelial sodium channel and mechanosensitive channels: a new gene superfamily (Symposium)
Rossier Bernard C. University of Lausanne - LA 01.07.1994 31.12.1994 Scientific Conferences

Mécanismes moléculaires impliqués dans la fonction et la régulation du canal épithelial au sodium ENaC
Schild Laurent University of Lausanne - LA 01.04.2005 31.03.2008 Project funding

Regulation of the epithelial Na+ channel (ENaC) by the ubiquitin-protein ligase Nedd4: Role in aldosterone response
Staub Olivier University of Lausanne - LA 01.04.1998 31.03.2001 Project funding

Hormonal control of sodium transport and organization of membrane polarity in epithelial cells
Rossier Bernard C. University of Lausanne - LA 01.10.1983 30.09.1986 Project funding

Maintaining homeostasis of extracellular fluids by the kidney: role of circadian and other mechanisms.
Firsov Dmitri University of Lausanne - LA 01.10.2010 30.09.2013 Project funding

Forefront in nephrology symposium: organization of membrane polarity in epithelial cells
Rossier Bernard C. University of Lausanne - LA 01.07.1989 31.12.1989 Scientific Conferences

Maintaining salt and water balance by the kidney: role of circulation timing system
Firsov Dmitri University of Lausanne - LA 01.10.2007 30.09.2010 Project funding

The control of blood pressure by the sympathetic nervous system
Atkinson Jeffrey University of Lausanne - LA 01.04.1984 31.03.1987 Project funding

Regulation of transepithelial NA+ transport in the distal bephron by ubiquitination and de-ubiquitination
Staub Olivier University of Lausanne - LA 01.04.2004 31.03.2009 Project funding

FXYD proteins: New regulators of Na,K-ATPase
Geering Käthi University of Lausanne - LA 01.04.2005 31.03.2008 Project funding

The AKAP-Lbc signaling complex: molecular characterization and functional implications
Diviani Dario University of Lausanne - LA 01.10.2002 30.09.2005 Project funding

Inducible nitric oxide synthase (INOS) activity in epithelial cells: role in differentiation and genotoxicity
Felley-Bosco Emanuela University of Lausanne - LA 01.04.1994 31.03.1997 Project funding

Mechanisms of function of acid-sensing ion channels (ASICs)
Kellenberger Stephan Beat University of Lausanne - LA 01.04.2011 31.03.2014 Project funding

In vivo relevance of the PY and PDZ-domain binding motifs of the cardiac sodium channel Nav1.5
Abriel Hugues University of Lausanne - LA 01.04.2008 31.03.2011 Project funding

Probing the molecular structure of the voltage-activated sodium channel: block by divalent cations and saxitoxin
Schild Laurent University of Lausanne - LA 01.04.1991 31.03.1994 Project funding

Modulation of ASICs and role of central domains in controlling their activity
Kellenberger Stephan Beat University of Lausanne - LA 01.04.2017 31.03.2021 Project funding

Contribution of acid-sensing ion channels (ASICs) to electrical signaling in neurons
Kellenberger Stephan Beat University of Lausanne - LA 01.10.2001 30.09.2004 Project funding

Subunit assembly, functional maturation and posttranslational regulation of Na,K-ATPase and H,K-ATPase
Geering Käthi University of Lausanne - LA 01.10.1992 30.09.1995 Project funding

Optimizing danger sensing: molecular, cellular and organismic strategies
Broillet Marie-Christine University of Lausanne - LA 01.04.2019 31.03.2023 Project funding

Development and preclinical assessment of a bioartificial pancreas
Thorens Bernard University of Lausanne - LA 01.01.2001 31.12.2003 NRP 46 Implants and Transplants

Transports transépithéliaux rénaux: effets des corticoides surrénaliens et de la néphrectomie unilatérale
Diezi Jacques University of Lausanne - LA 01.04.1985 31.03.1987 Project funding

Molecular and functional analysis of Na,K-ATPase subunit assemblyPhysiological and pharmacological aspects
Geering Käthi University of Lausanne - LA 01.10.1998 30.09.2001 Project funding

Transports transépithéliaux lors du développement tubulaire et après néphrectomie unilatérale
Diezi Jacques University of Lausanne - LA 01.04.1981 31.03.1983 Project funding

The epithelial sodium channel: structure, function and regulation
Schild Laurent University of Lausanne - LA 01.04.2008 31.03.2011 Project funding

Mechanisms of the renal excretion of urates, related organic anions and organic cations: micropuncture and microperfusion studies
Roch-Ramel Françoise University of Lausanne - LA 01.04.1977 31.03.1979 Project funding

Molecular physiology of Na,K-pump and basolateral K+ channels
Horisberger Jean-Daniel University of Lausanne - LA 01.04.1993 31.03.1996 Project funding

Regulation of surface expression of ion channels by the ubiqui- tin-protein ligase Nedd4
Staub Olivier University of Lausanne - LA 01.04.2001 31.03.2004 Project funding

Functional and morphological adaptation of the vertebrate kidney to reductions of renal mass
Diezi Jacques University of Lausanne - LA 01.04.1976 31.03.1977 Project funding

Transports transépithéliaux rénaux après néphrectomie unilatérale et lors du développement tubulaire
Diezi Jacques University of Lausanne - LA 01.04.1977 31.03.1979 Project funding

Investigation of anticancer mechanisms of polyphenols from Tetrapleura Tetraptera, xylopia parviflora, and other spices used in Cameroon
Pieme Constant Anatole University of Lausanne - LA 01.08.2014 31.10.2014 International short research visits

Renal calcium and uric acid handling and kidney stones
Bonny Olivier University of Lausanne - LA 01.10.2015 30.09.2018 Project funding

The role of the AKAP-Lbc signaling complex in G protein-coupled receptorinduced cardiac remodeling
Diviani Dario University of Lausanne - LA 01.10.2008 30.09.2011 Project funding

Understanding ASICs from the pH sensors to the gates
Kellenberger Stephan Beat University of Lausanne - LA 01.04.2014 31.03.2017 Project funding

Role of channel-activating proteases in epithelial ion transport
Hummler Edith University of Lausanne - LA 01.10.2018 30.09.2023 Project funding

Behavioral pharmacology: ingestive behaviors
Peters Georg University of Lausanne - LA 01.07.1977 30.06.1979 Project funding

Influence of circadian clock-coordinated post-transcriptional regulations on mouse liver metabolism
Gachon Frédéric University of Lausanne - LA 01.04.2010 31.08.2012 Project funding

Renal excretion and tubular transport of urea and organic ions
Roch-Ramel Françoise University of Lausanne - LA 01.04.1981 31.03.1983 Project funding

Glucose transporters and peptidic pancreatic beta cell receptors in the control of insulin and glucagon secretion
Thorens Bernard University of Lausanne - LA 01.07.1991 30.09.1996 Project funding

Ingestive behaviors: specific appetites, aversions, role of cholinergic and of peptidergic systems
Peters Georg University of Lausanne - LA 01.10.1985 30.09.1987 Project funding

3rd International Symposium on the ENaC/DEG gene superfamily
Horisberger Jean-Daniel University of Lausanne - LA 01.05.2000 28.02.2001 Scientific Conferences

Imbalance of biomineralization in kidney stone and bone
Bonny Olivier University of Lausanne - LA 01.10.2018 30.09.2022 Project funding

Inherited Channelopathies
Abriel Hugues University of Berne - BE 01.09.2010 30.09.2010 International Exploratory Workshops

Regulation of transepithelial sodium transport by hormonal and developmental factors
Rossier Bernard C. University of Lausanne - LA 01.10.1989 30.09.1992 Project funding

Co- and post-translational processing of oligomeric P-type ATP- ases
Geering Käthi University of Lausanne - LA 01.10.1995 30.09.1998 Project funding

Purification and reconstitution of renal organic ion trans- port systems
Schäli Christian University of Lausanne - LA 01.10.1984 30.09.1987 Project funding

Na, K-ATPase: structure, function and regulation in sodium trans-porting epithelia
Rossier Bernard C. University of Lausanne - LA 01.10.1992 30.09.1995 Project funding

Cellular biology of inducible nitric oxide synthase (INOS) in human epithelial cells
Felley-Bosco Emanuela University of Lausanne - LA 01.10.2001 30.09.2003 Project funding

"The mouse Grueneberg ganglion : a danger detector"
Broillet Marie-Christine University of Lausanne - LA 01.10.2009 31.03.2013 Project funding

Sensing chemical danger cues via the Grueneberg ganglion
Broillet Marie-Christine University of Lausanne - LA 01.04.2013 31.03.2016 Project funding

Na,K-ATPase: Biogenesis and regulation in development
Geering Käthi University of Lausanne - LA 01.10.1989 30.09.1992 Project funding

Cyclic nucleotide-gated channels: Their roles in neuronal development and sensory transduction cascades
Broillet Marie-Christine University of Lausanne - LA 01.04.2001 30.09.2003 Project funding

Etude d'une structure commune aux canaux ioniques ENaC et ASIC
Schild Laurent University of Lausanne - LA 01.04.2011 30.09.2014 Project funding

Psychology, physiology and pharmacology of ingestive behaviors
Peters Georg University of Lausanne - LA 01.10.1982 30.09.1985 Project funding

Renal tubular transport of non-polar and polar solutes.
Roch-Ramel Françoise University of Lausanne - LA 01.04.1979 31.03.1981 Project funding

Electrophysiological investigation of the effects of aldo- sterone in cultured cell lines
Horisberger Jean-Daniel University of Lausanne - LA 01.10.1987 31.03.1990 Project funding

The alpha1-adrenergic receptor: biochemical mechanisms of recep- tor function and regulation
Cotecchia Susanna University of Lausanne - LA 01.10.1992 30.09.1997 Project funding

Protein-protein interactions at the alpha1-adrenergic subtypes: molecular basis and functional implications
Cotecchia Susanna University of Lausanne - LA 01.04.2003 31.03.2009 Project funding

Mechanism of cation translocation by the Na, K-ATPase and related P-ATPases
Horisberger Jean-Daniel University of Lausanne - LA 01.10.2001 30.09.2006 Project funding

Protein-protein interactions in the regulation of Na,K-ATPase expression and function
Geering Käthi University of Lausanne - LA 01.10.2001 31.03.2005 Project funding

Physiological and pathophysiological role of CAP1 and ENaC in the epidermal permeability barrier function
Hummler Edith University of Lausanne - LA 01.10.2006 30.09.2009 Project funding

Molecular Physiology and Pathophysiology of the Cardiac Action Potential: Regulation of Nav 1.5
Abriel Hugues University of Lausanne - LA 01.04.2006 31.03.2008 SNSF Professorships

Determinants of ingestive behavior and neurobiological mechanisms
Peters Georg University of Lausanne - LA 01.10.1987 30.09.1990 Project funding

Molecular physiology and pathophysiology of the cardiac action potential: Regulation of hNav 1.5 and hErg
Abriel Hugues University of Lausanne - LA 01.04.2002 31.03.2006 SNSF Professorships

The alpha1-adrenergic receptor subtypes: structural basis of receptor function and drug action
Cotecchia Susanna University of Lausanne - LA 01.10.1997 31.03.2003 Project funding

Role of the stem cell antigen- 1 in the maintenance and self renewal of cardiac precursors in the heart
Rosenblatt-Velin Nathalie University of Lausanne - LA 01.10.2007 31.03.2008 Marie Heim-Voegtlin grants

Functional role of ENaC in skin, eye, and thymus by conditional gene targeting
Hummler Edith University of Lausanne - LA 01.04.1998 31.03.2001 Project funding

Cleavage-dependent and independent role of CAP1/Prss8 in physiological and pathophysiological conditions
Hummler Edith University of Lausanne - LA 01.10.2009 30.09.2012 Project funding

IIIrd European oocyte club meeting; the oocyte: A tool for the study of cellular and molecular processes
Geering Käthi University of Lausanne - LA 01.06.1993 30.11.1993 Scientific Conferences

Hormonal control of ion transporting epithelia
Rossier Bernard C. University of Lausanne - LA 01.10.1980 30.09.1983 Project funding

Mechanisms of urate transport by human renal plasma membranes.
Roch-Ramel Françoise University of Lausanne - LA 01.10.1995 30.09.1998 Project funding

Physiology and pharmacology of ingestive behaviors.
Peters Georg University of Lausanne - LA 01.07.1979 30.09.1982 Project funding

The epithelial sodium channel: structural basis for ion perme- ation and block by amiloride
Schild Laurent University of Lausanne - LA 01.04.1997 31.03.2000 Project funding

Hormonal control of ion transporting epithelia
Rossier Bernard C. University of Lausanne - LA 01.10.1978 30.09.1980 Project funding

Neuropeptide Y function is modulated by aminopeptidases
Grouzmann Eric University of Lausanne - LA 01.11.2003 31.03.2007 Project funding

Acid-sensing ion channels (ASICs): gating mechanisms and role in sensory neurons
Kellenberger Stephan Beat University of Lausanne - LA 01.10.2007 31.03.2011 Project funding

Regulation of sodium transport and Na,K-ATPase: develop- mental and hormonal factors
Rossier Bernard C. University of Lausanne - LA 01.10.1986 30.09.1989 Project funding

Interaction between membrane-bound proteases in development and organ function
Hummler Edith University of Lausanne - LA 01.10.2015 30.09.2018 Project funding

Hormonal control of transepithelial Na transport: action of aldosterone and related steroids
Rossier Bernard C. University of Lausanne - LA 01.10.1976 30.09.1978 Project funding

Cyclic nucleotide-gated channels: Multiple isoforms multiple roles
Broillet Marie-Christine University of Lausanne - LA 01.10.2003 30.09.2007 Project funding

Molecular characterization of a portal vein glucose sensor con- trolling glucose homeostasis
Burcelin Rémy University of Lausanne - LA 01.06.1999 31.05.2002 Project funding

Toxicité épithéliale du cadmium; effets rénaux des corticostéroides
Diezi Jacques University of Lausanne - LA 01.04.1987 31.03.1989 Project funding

Structure-function relationship of the Na,K-ATPase: Mechanism of cation translocation
Horisberger Jean-Daniel University of Lausanne - LA 01.04.1996 30.09.2001 Project funding

Contribution of intestinal epithelial inducible nitric oxide synthase (iNOS) to mucosal immunity.
Felley-Bosco Emanuela University of Lausanne - LA 01.04.2004 31.03.2006 Project funding

Molecular control of glucose homeostasis. Role of glucose trans- porters and hormone receptors
Thorens Bernard University of Lausanne - LA 01.10.1996 30.09.2001 Project funding

Development of the mammalian kidney
Diezi Jacques University of Lausanne - LA 01.07.1980 31.12.1980 Scientific Conferences

Regulation of membrane conductance in cultured high resistance epithelia
Horisberger Jean-Daniel University of Lausanne - LA 01.04.1990 31.03.1993 Project funding

Transports transépithéliaux lors du développement tubulaire et après néphrectomie unilatérale
Diezi Jacques University of Lausanne - LA 01.04.1983 31.03.1985 Project funding

Etudes de génomique, de protéomique et études fonctionnelles sur des segments de néphrons isolés
Schild Laurent University of Lausanne - LA 01.12.2009 30.11.2010 R'EQUIP

Mechanisms of action of antihypertensive drugs. Secretion and inactivation of renin
Peters Georg University of Lausanne - LA 01.04.1977 31.03.1979 Project funding

Congenital sodium diarrhea: the sole of SPINT2
Faller Nicolas University of Lausanne - LA 01.08.2009 31.07.2012 MD-PhD fellowships (funded by SNSF)

Function and regulation of the epithelial sodium channel (ENaC): a mutagenesis approach
Schild Laurent University of Lausanne - LA 01.04.2000 31.03.2005 Project funding

Chemical Danger Signaling via the Grueneberg Ganglion: From Volatile Molecules to Fear and Avoidance Behaviors
Broillet Marie-Christine University of Lausanne - LA 01.04.2016 31.03.2019 Project funding

Functional characterization of the EBV Latent membrane protein 1 (LMP1) variants in lymphoproliferative disorders. (MHV-Beitrag)
Rothenberger Aubert Sylvia University of Lausanne - LA 01.11.1997 31.10.1998 Marie Heim-Voegtlin grants

Function of acid-sensing ion channels (ASICs) in nociceptive neurons
Kellenberger Stephan Beat University of Lausanne - LA 01.10.2004 30.09.2007 Project funding

Control of renal ion homeostasis by ubiquitylation and AKAP2 dependent phosphorylation
Staub Olivier University of Lausanne - LA 01.10.2019 30.09.2023 Project funding
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