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Mycobacterium tuberculosis: mechanisms of virulence

Applicant Böttger Erik Christian
Number 68488
Funding scheme Project funding (Div. I-III)
Research institution Institut für Medizinische Mikrobiologie Universität Zürich
Institution of higher education University of Zurich - ZH
Main discipline Medical Microbiology
Start/End 01.10.2002 - 31.03.2008
Approved amount 798'000.00
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Keywords (5)

Tuberculosis; Mycobacterium; virulence; lipoprotein; phagosome maturation

Lay Summary (English)

Lay summary
Using a combination of molecular, genetic, biochemical and cell biology techniques along with in-vivo infection experiments we have characterized Mycobacterium tuberculosis factors involved in host-pathogen interaction: OmpA - a porin, LspA - a peptidase of the lipoprotein synthesis pathway, HbhA - an adhesin, Zmp1 - a zinc metalloprotease suppressing inflammasome activation. Mutants deficient in any of these genes show attenuation in various virulence models of infection. Given the important role of the lipoprotein synthesis pathway in mycobacterial pathogenesis we also studied Lgt and Lnt, two other enzymes involved in the synthesis of lipoproteins. Our analyses revealed the presence of an apo-lipoprotein N-acylase and a lipidation dependent protein translocation system.
Direct link to Lay Summary Last update: 21.02.2013

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Associated projects

Number Title Start Funding scheme
120326 Lipoproteins: Synthesis, localization and function in mycobacteria 01.04.2008 Project funding (Div. I-III)